Literature DB >> 18448790

Central nervous system regulation of energy metabolism: ghrelin versus leptin.

Ruben Nogueiras1, Matthias H Tschöp, Jeffrey M Zigman.   

Abstract

In this brief review, we introduce some major themes in the regulation of energy, lipid, and glucose metabolism by the central nervous system (CNS). Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS.

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Year:  2008        PMID： 18448790      PMCID： PMC2814160          DOI： 10.1196/annals.1433.054

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  40 in total

1.  Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.

Authors:  William P Esler; Joachim Rudolph; Thomas H Claus; Weifeng Tang; Nicole Barucci; Su-Ellen Brown; William Bullock; Michelle Daly; Lynn Decarr; Yaxin Li; Lucinda Milardo; David Molstad; Jian Zhu; Stephen J Gardell; James N Livingston; Laurel J Sweet
Journal:  Endocrinology       Date:  2007-07-26       Impact factor: 4.736

2.  Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.

Authors:  A Asakawa; A Inui; T Kaga; H Yuzuriha; T Nagata; N Ueno; S Makino; M Fujimiya; A Niijima; M A Fujino; M Kasuga
Journal:  Gastroenterology       Date:  2001-02       Impact factor: 22.682

3.  A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.

Authors:  D E Cummings; J Q Purnell; R S Frayo; K Schmidova; B E Wisse; D S Weigle
Journal:  Diabetes       Date:  2001-08       Impact factor: 9.461

4.  Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.

Authors:  B Otto; U Cuntz; E Fruehauf; R Wawarta; C Folwaczny; R L Riepl; M L Heiman; P Lehnert; M Fichter; M Tschöp
Journal:  Eur J Endocrinol       Date:  2001-11       Impact factor: 6.664

5.  A role for ghrelin in the central regulation of feeding.

Authors:  M Nakazato; N Murakami; Y Date; M Kojima; H Matsuo; K Kangawa; S Matsukura
Journal:  Nature       Date:  2001-01-11       Impact factor: 49.962

6.  Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins.

Authors:  E Ravussin; M Tschöp; S Morales; C Bouchard; M L Heiman
Journal:  J Clin Endocrinol Metab       Date:  2001-09       Impact factor: 5.958

7.  Central melanocortin receptors regulate insulin action.

Authors:  S Obici; Z Feng; J Tan; L Liu; G Karkanias; L Rossetti
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

8.  Weight loss increases circulating levels of ghrelin in human obesity.

Authors:  Troels Krarup Hansen; Rolf Dall; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Jens Sandahl Christiansen; Jens Otto Lunde Jørgensen
Journal:  Clin Endocrinol (Oxf)       Date:  2002-02       Impact factor: 3.478

9.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

Authors:  M Kojima; H Hosoda; Y Date; M Nakazato; H Matsuo; K Kangawa
Journal:  Nature       Date:  1999-12-09       Impact factor: 49.962

10.  Circulating ghrelin levels are decreased in human obesity.

Authors:  M Tschöp; C Weyer; P A Tataranni; V Devanarayan; E Ravussin; M L Heiman
Journal:  Diabetes       Date:  2001-04       Impact factor: 9.461
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  42 in total

1.  Insufficient sleep undermines dietary efforts to reduce adiposity.

Authors:  Arlet V Nedeltcheva; Jennifer M Kilkus; Jacqueline Imperial; Dale A Schoeller; Plamen D Penev
Journal:  Ann Intern Med       Date:  2010-10-05       Impact factor: 25.391

Review 2.  A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis.

Authors:  Claudia R Vianna; Roberto Coppari
Journal:  Endocrinology       Date:  2010-11-10       Impact factor: 4.736

3.  Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons.

Authors:  Tadasuke Komori; Asako Doi; Hiroto Furuta; Hiroshi Wakao; Naoyuki Nakao; Masamitsu Nakazato; Kishio Nanjo; Emiko Senba; Yoshihiro Morikawa
Journal:  J Biol Chem       Date:  2010-09-28       Impact factor: 5.157

4.  Activating mu-opioid receptors in the lateral parabrachial nucleus increases c-Fos expression in forebrain areas associated with caloric regulation, reward and cognition.

Authors:  M Denbleyker; D M Nicklous; P J Wagner; H G Ward; K J Simansky
Journal:  Neuroscience       Date:  2009-05-05       Impact factor: 3.590

5.  Relationship between body mass index, alcohol use, and alcohol misuse in a young adult female twin sample.

Authors:  Alexis E Duncan; Julia D Grant; Kathleen Keenan Bucholz; Pamela A F Madden; Andrew C Heath
Journal:  J Stud Alcohol Drugs       Date:  2009-05       Impact factor: 2.582

Review 6.  Brain Glucose-Sensing Mechanism and Energy Homeostasis.

Authors:  A J López-Gambero; F Martínez; K Salazar; M Cifuentes; F Nualart
Journal:  Mol Neurobiol       Date:  2018-05-24       Impact factor: 5.590

7.  Expression of the diabetes-associated gene TCF7L2 in adult mouse brain.

Authors:  Syann Lee; Charlotte E Lee; Carol F Elias; Joel K Elmquist
Journal:  J Comp Neurol       Date:  2009-12-20       Impact factor: 3.215

8.  Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain.

Authors:  Mario Perello; Michael M Scott; Ichiro Sakata; Charlotte E Lee; Jen-Chieh Chuang; Sherri Osborne-Lawrence; Sherry A Rovinsky; Joel K Elmquist; Jeffrey M Zigman
Journal:  J Comp Neurol       Date:  2012-02-01       Impact factor: 3.215

9.  Changes in Appetite Regulation-Related Signaling Pathways in the Brain of Mice Supplemented with Non-nutritive Sweeteners.

Authors:  Gerson G Contreras-Chavez; José A Estrada; Irazú Contreras
Journal:  J Mol Neurosci       Date:  2020-10-31       Impact factor: 3.444

10.  Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists.

Authors:  Anna-Sophia Wisser; Piet Habbel; Bertram Wiedenmann; Burghard F Klapp; Hubert Mönnikes; Peter Kobelt
Journal:  Int J Pept       Date:  2010-01-06
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