BACKGROUND: Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels. OBJECTIVE: Authors sought to investigate quality of life (QoL) in MFS patients, assessing positive and negative sociodemographic factors and self-perceived well-being and functional status. METHOD: Thirty-six patients affected by MFS were interviewed and were administered the SF-36 psychometric questionnaire. RESULTS: Subjects affected by MFS reported an impaired quality of life in the psychological domain but not in the physical domain, as compared with a healthy population. Being male and older was significantly associated with a poorer perceived mental QoL. CONCLUSION: The authors found that MFS negatively influences QoL, increases psychological distress, and may be a possible risk for some psychiatric disorders.
BACKGROUND:Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels. OBJECTIVE: Authors sought to investigate quality of life (QoL) in MFSpatients, assessing positive and negative sociodemographic factors and self-perceived well-being and functional status. METHOD: Thirty-six patients affected by MFS were interviewed and were administered the SF-36 psychometric questionnaire. RESULTS: Subjects affected by MFS reported an impaired quality of life in the psychological domain but not in the physical domain, as compared with a healthy population. Being male and older was significantly associated with a poorer perceived mental QoL. CONCLUSION: The authors found that MFS negatively influences QoL, increases psychological distress, and may be a possible risk for some psychiatric disorders.
Authors: Judith Z Goldfinger; Liliana R Preiss; Richard B Devereux; Mary J Roman; Tabitha P Hendershot; Barbara L Kroner; Kim A Eagle Journal: J Am Coll Cardiol Date: 2017-06-13 Impact factor: 24.094
Authors: Jill C Handisides; Danielle Hollenbeck-Pringle; Karen Uzark; Felicia L Trachtenberg; Victoria L Pemberton; Teresa W Atz; Timothy J Bradley; Elizabeth Cappella; Sylvia De Nobele; Georgeann Keh-Teng Groh; Michelle S Hamstra; Rosalind Korsin; Jami C Levine; Bergen Lindauer; Aimee Liou; Meghan K Mac Neal; Larry W Markham; Tonia Morrison; Kathleen A Mussatto; Aaron K Olson; Mary Ella M Pierpont; Reed E Pyeritz; Elizabeth A Radojewski; Mary J Roman; Mingfen Xu; Ronald V Lacro Journal: J Pediatr Date: 2018-09-27 Impact factor: 4.406
Authors: Caroline Andonian; Sebastian Freilinger; Stefan Achenbach; Peter Ewert; Ulrike Gundlach; Harald Kaemmerer; Nicole Nagdyman; Rhoia Clara Neidenbach; Lars Pieper; Jörg Schelling; Michael Weyand; Jürgen Beckmann Journal: Cardiovasc Diagn Ther Date: 2021-04
Authors: Dounya Schoormans; Teodora Radonic; Piet de Witte; Maarten Groenink; Donija Azim; Rene Lutter; Barbara J M Mulder; Mirjam A G Sprangers; Aeilko H Zwinderman Journal: PLoS One Date: 2012-09-25 Impact factor: 3.240