| Literature DB >> 18447358 |
Chongkham S Mekmaysy1, Luigi Petraccone, Nichola C Garbett, Patricia A Ragazzon, Robert Gray, John O Trent, Jonathan B Chaires.
Abstract
The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure.Entities:
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Year: 2008 PMID： 18447358 DOI： 10.1021/ja801976h
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419