BACKGROUND: The classic triad of symptoms seen in chronic mesenteric ischaemia is post-prandial pain, sitophobia (fear of food) and progressive weight loss. Patients with mesenteric ischaemia secondary to a prothrombotic state such as that rendered by the Factor V Leiden mutation, are substantially younger than the typical elderly patient in whom embolic disease triggered by atrial fibrillation is the main underlying cause. METHOD: This is one such case report documenting arterial thrombosis in a 37-year-old male with a subsequently identified heterozygous Factor V Leiden mutation. CONCLUSION: Factor V Leiden mutation is a contributing risk factor in cases of small bowel infarction.
BACKGROUND: The classic triad of symptoms seen in chronic mesenteric ischaemia is post-prandial pain, sitophobia (fear of food) and progressive weight loss. Patients with mesenteric ischaemia secondary to a prothrombotic state such as that rendered by the Factor V Leiden mutation, are substantially younger than the typical elderly patient in whom embolic disease triggered by atrial fibrillation is the main underlying cause. METHOD: This is one such case report documenting arterial thrombosis in a 37-year-old male with a subsequently identified heterozygous Factor V Leiden mutation. CONCLUSION:Factor V Leiden mutation is a contributing risk factor in cases of small bowel infarction.
Authors: D Heresbach; M Pagenault; P Gueret; P Crenn; N Heresbach-Le Berre; Y Malledant; R Fauchet; M H Horellou; J Silver; B Messing; J F Bretagne Journal: Gastroenterology Date: 1997-07 Impact factor: 22.682