Literature DB >> 184461

Incorporation of adenosine into ATP: formation of compartmentalized ATP.

E Rapaport, P C Zamecnik.   

Abstract

The incorporation of [3H]adenosine, [3H]adenine, and [3H]hypoxanthine into adenine nucleotides of nude (athymic) mouse liver and human hepatoma grown subcutaneously in nude mice was studied. 3H and 32P radioactive labeling in vivo of acid-soluble nucleotides followed by chromatographic procedures indicated that, in contrast to [3H]adenine and [3H]hypoxanthine, [3H]adenosine is preferentially incorporated into ATP in comparison with its incorporation into AMP and ADP. This phenomenon, as well as complementing the recently reported 3-fold increase in total cellular ATP upon treatmen- with 0.5-1.0 mM concentrations of adenosine, indicates the formation from adenosine of compartmentalized ATP that is not produced from either adenine or hypoxanthine. The observed effect is of larger magnitude in the growth-arrested normal liver than in the actively growing tumor.

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Year:  1976        PMID： 184461      PMCID： PMC430951          DOI： 10.1073/pnas.73.9.3122

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  The dependence of glucose formation from lactate on the adenosine triphosphate content in the isolated perfused rat liver.

Authors:  J Wilkening; J Nowack; K Decker
Journal:  Biochim Biophys Acta       Date:  1975-06-12

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Authors:  A WOLLENBERGER; O RISTAU; G SCHOFFA
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3.  The kinetics of serum-induced initiation of DNA synthesis in BHK 21/C13 cells, and the influence of exogenous adenosine.

Authors:  R F Brooks
Journal:  J Cell Physiol       Date:  1975-10       Impact factor: 6.384

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Authors:  R CAPUTTO
Journal:  J Biol Chem       Date:  1951-04       Impact factor: 5.157

Review 5.  Purine ribonucleotide catabolism: clinical and biochemical significance. Review.

Authors:  I H Fox
Journal:  Nutr Metab       Date:  1974       Impact factor: 4.169

6.  Metabolism of hepatomas of different growth rates in situ and during ischemia.

Authors:  G Weber; M Stubbs; H P Morris
Journal:  Cancer Res       Date:  1971-12       Impact factor: 12.701

7.  Human phosphoribosylpyrophosphate synthetase. Kinetic mechanism and end product inhibition.

Authors:  I H Fox; W N Kelley
Journal:  J Biol Chem       Date:  1972-04-10       Impact factor: 5.157

8.  Adenosine triphosphate conservation in biosynthetic regulation. Escherichia coli phosphoribosylpyrophosphate synthase.

Authors:  D E Atkinson; L Fall
Journal:  J Biol Chem       Date:  1967-07-10       Impact factor: 5.157

9.  Effect of adenosine on the adenine nucleotide content and metabolism of hepatocytes.

Authors:  P Lund; N W Cornell; H A Krebs
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

10.  Nucleotide pools in Novikoff rat hepatoma cells growing in suspension culture. 3. Effects of nucleosides in medium on levels of nucleotides in separate nucleotide pools for nuclear and cytoplasmic RNA synthesis.

Authors:  P G Plagemann
Journal:  J Cell Biol       Date:  1972-01       Impact factor: 10.539
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  13 in total

1.  Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator".

Authors:  E Rapaport; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

2.  Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor.

Authors:  G Thomas; M Siegmann; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

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Authors:  E Rapaport; M A Garcia-Blanco; P C Zamecnik
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4.  Responses of adenine nucleotides in germinating soybean embryonic axes to exogenously applied adenine and adenosine.

Authors:  J D Anderson
Journal:  Plant Physiol       Date:  1977-11       Impact factor: 8.340

5.  Purine nucleotide metabolism of germinating soybean embryonic axes.

Authors:  J D Anderson
Journal:  Plant Physiol       Date:  1979-01       Impact factor: 8.340

6.  Continuous intravenous infusion of ATP in humans yields large expansions of erythrocyte ATP pools but extracellular ATP pools are elevated only at the start followed by rapid declines.

Authors:  Eliezer Rapaport; Anna Salikhova; Edward H Abraham
Journal:  Purinergic Signal       Date:  2015-04-29       Impact factor: 3.765

7.  A comparison of adenine and some derivatives on pig isolated tracheal muscle.

Authors:  Y Bach-Dieterle; W E Holden; A F Junod
Journal:  Br J Pharmacol       Date:  1983-12       Impact factor: 8.739

8.  Some further observations on the stimulation by high external potassium of the sodium efflux in barnacle muscle fibers.

Authors:  E E Bittar; J Nwoga
Journal:  Pflugers Arch       Date:  1982-12       Impact factor: 3.657

9.  Both hypoxanthine and adenosine stimulate DNA synthesis independently in serum-starved L cells treated with platelet protein.

Authors:  H Klenow; H Flodgaard
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

10.  Increased incorporation of adenosine into adenine nucleotide pools in serum-deprived mammalian cells.

Authors:  E Rapaport; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205
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