| Literature DB >> 18445833 |
Abstract
Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.Mesh:
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Year: 2008 PMID: 18445833 DOI: 10.1126/stke.117pe17
Source DB: PubMed Journal: Sci Signal ISSN: 1945-0877 Impact factor: 8.192