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Literature DB >> 18445528

Efficient synthesis and evaluation of bimodal ligand NETA.

Hyun-Soon Chong¹, Hyun A Song, Noah Birch, Thien Le, Sooyoun Lim, Xiang Ma.

Abstract

The efficient and short synthetic route to the structurally novel bimodal ligand NETA for antibody-targeted radiation therapy (radioimmunotherapy, RIT) of cancer was developed. The structure of NETA was determined by X-ray crystallography. The arsenazo-based UV spectroscopic complexation kinetics data suggest that NETA is a promising chelator for use in RIT applications of (212)Bi, (213)Bi, and (177)Lu.

Entities: Chemical Disease

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Year: 2008 PMID： 18445528 DOI： 10.1016/j.bmcl.2008.03.084

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

12 in total

1. Novel (64)Cu-radiolabeled bile acid conjugates for targeted PET imaging.

Authors: Hyun-Soon Chong; Yunwei Chen; Chi Soo Kang; Xiang Sun; Ningjie Wu
Journal: Bioorg Med Chem Lett Date: 2015-01-12 Impact factor: 2.823

2. Novel hexadentate and pentadentate chelators for ⁶⁴Cu-based targeted PET imaging.

Authors: Inseok Sin; Chi Soo Kang; Nilantha Bandara; Xiang Sun; Yongliang Zhong; Buck E Rogers; Hyun-Soon Chong
Journal: Bioorg Med Chem Date: 2014-03-01 Impact factor: 3.641

3. Synthesis and comparative biological evaluation of bifunctional ligands for radiotherapy applications of (90)Y and (177)Lu.

Authors: Hyun-Soon Chong; Xiang Sun; Yunwei Chen; Inseok Sin; Chi Soo Kang; Michael R Lewis; Dijie Liu; Varyanna C Ruthengael; Yongliang Zhong; Ningjie Wu; Hyun A Song
Journal: Bioorg Med Chem Date: 2014-12-23 Impact factor: 3.641

4. Preclinical evaluation of NETA-based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: radiolabeling, serum stability, and biodistribution and tumor uptake studies.

Authors: Chi Soo Kang; Hyun A Song; Diane E Milenic; Kwamena E Baidoo; Martin W Brechbiel; Hyun-Soon Chong
Journal: Nucl Med Biol Date: 2013-03-27 Impact factor: 2.408

10. Pyridine-containing octadentate ligand NE3TA-PY for formation of neutral complex with ¹⁷⁷Lu(III) and ⁹⁰Y(III) for radiopharmaceutical applications: Synthesis, DFT calculation, radiolabeling, and in vitro complex stability.

Authors: Hyun-Soon Chong; Yunwei Chen; Chi Soo Kang; Inseok Sin; Shuyuan Zhang; Haixing Wang
Journal: J Inorg Biochem Date: 2021-04-24 Impact factor: 4.336

Efficient synthesis and evaluation of bimodal ligand NETA.

1. Novel (64)Cu-radiolabeled bile acid conjugates for targeted PET imaging.

2. Novel hexadentate and pentadentate chelators for ⁶⁴Cu-based targeted PET imaging.

3. Synthesis and comparative biological evaluation of bifunctional ligands for radiotherapy applications of (90)Y and (177)Lu.

4. Preclinical evaluation of NETA-based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: radiolabeling, serum stability, and biodistribution and tumor uptake studies.

5. Convenient Synthesis and Evaluation of Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications.

6. Synthesis and evaluation of a new bifunctional NETA chelate for molecular targeted radiotherapy using(90)Y or(177)Lu.

7. Novel bimodal bifunctional ligands for radioimmunotherapy and targeted MRI.

8. Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development.

Review 9. Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside.

10. Pyridine-containing octadentate ligand NE3TA-PY for formation of neutral complex with ¹⁷⁷Lu(III) and ⁹⁰Y(III) for radiopharmaceutical applications: Synthesis, DFT calculation, radiolabeling, and in vitro complex stability.