| Literature DB >> 18445525 |
Junko Tamiya1, Brian Dyck, Mingzhu Zhang, Kasey Phan, Beth A Fleck, Anna Aparicio, Florence Jovic, Joe A Tran, Troy Vickers, Jonathan Grey, Alan C Foster, Chen Chen.
Abstract
A series of milnacipran analogs were synthesized and studied as monoamine transporter inhibitors, and several potent compounds with moderate lipophilicity were identified from the 1S,2R-isomers. Thus, 15l exhibited IC(50) values of 1.7nM at NET and 25nM at SERT, which were, respectively, 20- and 13-fold more potent than 1S,2R-milnacipran 1-II.Entities:
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Year: 2008 PMID： 18445525 DOI： 10.1016/j.bmcl.2008.04.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823