| Literature DB >> 18444675 |
Yichun Liu1, Mingya Zhong, Guiye Shan, Yajun Li, Baiqu Huang, Guoliang Yang.
Abstract
A novel method for identifying DNA microarrays based on ZnO/Au nanocomposites functionalized with thiol-oligonucleotide as probes is descried here. DNA labeled with ZnO/Au nanocomposites has a strong Raman signal even without silver acting as a surface-enhanced Raman scattering promoter. X-ray photoelectron spectra confirmed the formation of a three-component sandwich assay, i.e., constituted DNA and ZnO/Au nanocomposites. The resonance multiple-phonon Raman signal of the ZnO/Au nanocomposites as a spectroscopic fingerprint is used to detect a target sequence of oligonucleotide. This method exhibits extraordinary sensitivity and the detection limit is at least 1 fM.Entities:
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Year: 2008 PMID: 18444675 DOI: 10.1021/jp710399d
Source DB: PubMed Journal: J Phys Chem B ISSN: 1520-5207 Impact factor: 2.991