AIM: To assess the performance of a novel hand-held nitric oxide (NO) analyzer in the measurement of nasal fractional exhaled NO (FE(NO)). METHODS: In ten healthy subjects (controls) and ten patients with chronic rhinosinusitis (CRS), oral and nasal FENO were obtained with the NIOX MINO Airway Inflammation Monitor (Aerocrine AB, Solna, Sweden) on two consecutive days, complying with current standards. RESULTS: Intraclass correlation coefficient (ICC) of oral FENO was 0.91 and of nasal FE(NO) 0.79. In controls, mean (+/- SD) nasal FENO (40.3 +/- 23.6 ppb) was higher than oral FENO (15.6 +/- 2.7 ppb; p = 0.005). In CRS patients, mean oral FENO (23.9 +/- 12.2 ppb) was higher than in controls (15.6 +/- 2.7 ppb; p = 0.01). CRS patients with nasal polyps had lower nasal FE(NO) levels (19.7 +/- 5.9) than healthy controls (40.3 +/- 23.6 ppb; p = 0.01). CONCLUSIONS: The novel hand-held NO analyzer was found suitable for nasal FE(NO) measurements. It may be useful in differentiating hyperplasic eosinophil rhinosinusitis from chronic unspecific rhinosinusitis. Moreover, nasal FE(NO) may be used to monitor the clinical course of CRS with polyps.
AIM: To assess the performance of a novel hand-held nitric oxide (NO) analyzer in the measurement of nasal fractional exhaled NO (FE(NO)). METHODS: In ten healthy subjects (controls) and ten patients with chronic rhinosinusitis (CRS), oral and nasal FENO were obtained with the NIOX MINO Airway Inflammation Monitor (Aerocrine AB, Solna, Sweden) on two consecutive days, complying with current standards. RESULTS: Intraclass correlation coefficient (ICC) of oral FENO was 0.91 and of nasal FE(NO) 0.79. In controls, mean (+/- SD) nasal FENO (40.3 +/- 23.6 ppb) was higher than oral FENO (15.6 +/- 2.7 ppb; p = 0.005). In CRSpatients, mean oral FENO (23.9 +/- 12.2 ppb) was higher than in controls (15.6 +/- 2.7 ppb; p = 0.01). CRSpatients with nasal polyps had lower nasal FE(NO) levels (19.7 +/- 5.9) than healthy controls (40.3 +/- 23.6 ppb; p = 0.01). CONCLUSIONS: The novel hand-held NO analyzer was found suitable for nasal FE(NO) measurements. It may be useful in differentiating hyperplasic eosinophil rhinosinusitis from chronic unspecific rhinosinusitis. Moreover, nasal FE(NO) may be used to monitor the clinical course of CRS with polyps.
Authors: Yogesh G Dabholkar; Akanksha A Saberwal; Haritosh K Velankar; Adip K Shetty; Nilesh P Chordia; Sneha R Budhwani Journal: Indian J Otolaryngol Head Neck Surg Date: 2013-11-20
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Authors: Pasquale Ambrosino; Antonio Molino; Giorgio Alfredo Spedicato; Paolo Parrella; Roberto Formisano; Andrea Motta; Matteo Nicola Dario Di Minno; Mauro Maniscalco Journal: J Clin Med Date: 2020-01-11 Impact factor: 4.241