Literature DB >> 18443957

Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells.

Junming Guo1, Bingxiu Xiao, Qiong Liu, Zhaohui Gong, Yanping Le.   

Abstract

Aloe-emodin is a hydroxyanthraquinone found in Aloe vera, as well as in leaves and roots of other plants. The mechanisms of its anticancer effect are largely unknown. The present study investigated its molecular mechanisms. Crystal violet assay showed that aloe-emodin had a long-term anti-proliferation effect on human gastric cancer MGC-803 and SGC-7901 cells. Scratch wound-healing motility assays indicated its anti-migration effect. Aloe-emodin arrested SGC-7901 cells at G2/M phase. More importantly, aloe-emodin inhibited the expressions of protein kinase C and c-myc. In conclusion, the anticancer effect of aloe-emodin on gastric cancer cells involves suppression of c-myc expression.

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Year:  2008        PMID： 18443957     DOI： 10.1080/07357900701788130

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  15 in total

1.  Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2.

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Journal:  Carcinogenesis       Date:  2012-04-24       Impact factor: 4.944

2.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

3.  Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation.

Authors:  Xiaobin Chang; Jimin Zhao; Fang Tian; Yanan Jiang; Jing Lu; Junfen Ma; Xiaoyan Zhang; Guoguo Jin; Youtian Huang; Zigang Dong; Kangdong Liu; Ziming Dong
Journal:  Oncol Lett       Date:  2016-07-25       Impact factor: 2.967

4.  Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1.

Authors:  Wei Qu; Yufei Wang; Qining Wu; Jijun Liu; Dingjun Hao
Journal:  Int J Clin Exp Med       Date:  2015-09-15

5.  Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide.

Authors:  Ying Miao; Bingxiu Xiao; Zhen Jiang; Yanan Guo; Fang Mao; Junwei Zhao; Xia Huang; Junming Guo
Journal:  Med Oncol       Date:  2009-08-11       Impact factor: 3.064

6.  Anti-tumor effect of emodin on gynecological cancer cells.

Authors:  Yaoxian Wang; Hui Yu; Jin Zhang; Xin Ge; Jing Gao; Yunyan Zhang; Ge Lou
Journal:  Cell Oncol (Dordr)       Date:  2015-07-11       Impact factor: 6.730

7.  Involvement of matrix metalloproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells.

Authors:  Hsu-Feng Lu; Kuang-Chi Lai; Shu-Chun Hsu; Hui-Ju Lin; Chao-Lin Kuo; Ching-Lung Liao; Jai-Sing Yang; Jing-Gung Chung
Journal:  Neurochem Res       Date:  2009-03-17       Impact factor: 3.996

8.  Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest.

Authors:  Fang Mao; Bingxiu Xiao; Zhen Jiang; Junwei Zhao; Xia Huang; Junming Guo
Journal:  Med Oncol       Date:  2010-01-12       Impact factor: 3.064

9.  Expression and role of grainyhead-like 2 in gastric cancer.

Authors:  Jifeng Xiang; Xiang Fu; Wenhua Ran; Xuan Chen; Zhen Hang; Hongchao Mao; Ziwei Wang
Journal:  Med Oncol       Date:  2013-09-26       Impact factor: 3.064

10.  Anti-cancer effects of aloe-emodin: a systematic review.

Authors:  Brian Sanders; Anna M Ray; Sharon Goldberg; Tyler Clark; H Reginald McDaniel; Steven E Atlas; Ashar Farooqi; Janet Konefal; Lucas C Lages; Johanna Lopez; Ammar Rasul; Eduard Tiozzo; Judi M Woolger; John E Lewis
Journal:  J Clin Transl Res       Date:  2017-09-07
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