| Literature DB >> 18443737 |
William J Muller1, Nural N Orgun, Lichun Dong, David M Koelle, Meei-Li Huang, Sing Sing Way.
Abstract
Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.Entities:
Mesh:
Substances:
Year: 2008 PMID: 18443737 PMCID: PMC2635120 DOI: 10.1007/s00705-008-0089-7
Source DB: PubMed Journal: Arch Virol ISSN: 0304-8608 Impact factor: 2.574