OBJECTIVE: The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues. STUDY DESIGN: Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time. RESULTS: In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days. CONCLUSION: Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.
OBJECTIVE: The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues. STUDY DESIGN:Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time. RESULTS: In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days. CONCLUSION: Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.
Authors: André Af Marques; Emilio C Sponchiado; Lucas Fr Garcia; Angela Db Garrido; Suzelei C França; Raphael Cc Lia Journal: J Conserv Dent Date: 2011-07
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Authors: Grzegorz Szczurko; Małgorzata Pawińska; Elżbieta Łuczaj-Cepowicz; Anna Kierklo; Grażyna Marczuk-Kolada; Adam Hołownia Journal: Odontology Date: 2017-12-14 Impact factor: 2.634