Y A Wang1, D Healy, D Black, E A Sullivan. 1. Perinatal and Reproductive Epidemiology Research Unit, School of Women's and Children's Health, The University of New South Wales, McNevin Dickson Building, Randwick Hospitals Campus, Randwick, NSW 2031, Australia. alex.wang@unsw.edu.au
Abstract
BACKGROUND: Woman's age is an independent factor determining the success of assisted reproductive technology treatment. This study presents the age-specific success rate of first autologous fresh treatment in Australia during 2002-2005. METHODS: This is a retrospective population-based study of 36,412 initiated first autologous fresh cycles conducted in Australian clinics during 2002-2005. Pregnancy and live delivery rates per initiated cycle were determined for each age. RESULTS: The overall live delivery rate per initiated cycle was 20.4% with the highest success rate in women aged between 22 and 36 years. Male factor only infertility had a higher live delivery rate (22.0%) than female factor only infertility (19.2%). Advancing woman's age was associated with a decline in success rate. For women > or = 30 years, each additional 1 year in age was associated with an 11% (99% CI: 10-12%) reduction in the chance of achieving pregnancy and a 13% (99% CI: 12-14%) reduction in the chance of a live delivery. If women aged 35 years or older would have had their first autologous fresh treatment 1 year earlier, 15% extra live deliveries would be expected. CONCLUSIONS: This study suggested that women aged 35 years or older should be encouraged to seek early fertility assessment and treatment where clinically indicated.
BACKGROUND:Woman's age is an independent factor determining the success of assisted reproductive technology treatment. This study presents the age-specific success rate of first autologous fresh treatment in Australia during 2002-2005. METHODS: This is a retrospective population-based study of 36,412 initiated first autologous fresh cycles conducted in Australian clinics during 2002-2005. Pregnancy and live delivery rates per initiated cycle were determined for each age. RESULTS: The overall live delivery rate per initiated cycle was 20.4% with the highest success rate in women aged between 22 and 36 years. Male factor only infertility had a higher live delivery rate (22.0%) than female factor only infertility (19.2%). Advancing woman's age was associated with a decline in success rate. For women > or = 30 years, each additional 1 year in age was associated with an 11% (99% CI: 10-12%) reduction in the chance of achieving pregnancy and a 13% (99% CI: 12-14%) reduction in the chance of a live delivery. If women aged 35 years or older would have had their first autologous fresh treatment 1 year earlier, 15% extra live deliveries would be expected. CONCLUSIONS: This study suggested that women aged 35 years or older should be encouraged to seek early fertility assessment and treatment where clinically indicated.
Authors: S Høyer; A H Riis; G Toft; L A Wise; E E Hatch; A K Wesselink; K J Rothman; H T Sørensen; E M Mikkelsen Journal: Hum Reprod Date: 2020-04-28 Impact factor: 6.918
Authors: José G Franco; Claudia G Petersen; Ana L Mauri; Laura D Vagnini; Adriana Renzi; Bruna Petersen; M C Mattila; Vanessa A Comar; Juliana Ricci; Felipe Dieamant; João Batista A Oliveira; Ricardo L R Baruffi Journal: JBRA Assist Reprod Date: 2017-06-01