| Literature DB >> 184412 |
I C Calder, D E Goss, P J Williams, C C Funder, C R Green, K N Ham, J D Tange.
Abstract
N-hydroxyphenacetin, a phenacetin metabolite, was fed to rats as a 0.05-0.5% dietary supplement. After 9 months, tumours of the liver were found in 36 of 64 animals. One animal also developed a renal tumour. No tumours were found in control animals. The findings implicate phenacetin as a carcinogen and suggest that N-hydroxyphenacetin may be the metabolite responsible.Entities:
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Year: 1976 PMID： 184412 DOI： 10.3109/00313027609094418
Source DB: PubMed Journal: Pathology ISSN： 0031-3025 Impact factor: 5.306