| Literature DB >> 18440869 |
Jinhua Zhou1, Tao Zhu, Chunxia Hu, Hongyu Li, Gang Chen, Gang Xu, Shixuan Wang, Jianfeng Zhou, Ding Ma.
Abstract
Bax inhibitor-1 (BI1) family contains six known genes in human. Some members of BI1 family have been proved to play important roles in cell death. Here we discuss the similarities and differences among the members of BI1 family by comparative genomics and proteomics, and report here the discovery of a novel member, tmbim1b, in Bos taurus. BI1 family is evolutionarily conserved as integral membrane proteins containing multiple membrane-spanning segments and predominantly localized to intracellular membranes, similar to Bcl-2 family proteins. They share multiple motifs and transcriptional factors within the promoter and the coding regions. They may represent regulators of cell death pathways, which are concluded from structure conservation of BI1 family.Entities:
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Year: 2008 PMID： 18440869 DOI： 10.1016/j.compbiolchem.2008.01.002
Source DB: PubMed Journal: Comput Biol Chem ISSN： 1476-9271 Impact factor: 2.877