Literature DB >> 18440814

Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.

Yuefen Zhou1, Chun Chow, Douglas E Murphy, Zhongxiang Sun, Thomas Bertolini, Jamie M Froelich, Stephen E Webber, Thomas Hermann, Daniel Wall.   

Abstract

Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.

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Year:  2008        PMID： 18440814      PMCID： PMC2474707          DOI： 10.1016/j.bmcl.2008.04.023

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Piperidine glycosides targeting the ribosomal decoding site.

Authors:  Klaus B Simonsen; Benjamin K Ayida; Dionisios Vourloumis; Geoffrey C Winters; Masayuki Takahashi; Sarah Shandrick; Qiang Zhao; Thomas Hermann
Journal:  Chembiochem       Date:  2003-09-05       Impact factor: 3.164

2.  Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site.

Authors:  Dionisios Vourloumis; Geoffrey C Winters; Masayuki Takahashi; Klaus B Simonsen; Benjamin K Ayida; Sarah Shandrick; Qiang Zhao; Thomas Hermann
Journal:  Chembiochem       Date:  2003-09-05       Impact factor: 3.164

Review 3.  2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics.

Authors:  Guuske F Busscher; Floris P J T Rutjes; Floris L van Delft
Journal:  Chem Rev       Date:  2005-03       Impact factor: 60.622

Review 4.  Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America.

Authors:  George H Talbot; John Bradley; John E Edwards; David Gilbert; Michael Scheld; John G Bartlett
Journal:  Clin Infect Dis       Date:  2005-01-25       Impact factor: 9.079

5.  Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.

Authors:  Yuefen Zhou; Vlad E Gregor; Zhongxiang Sun; Benjamin K Ayida; Geoffrey C Winters; Douglas Murphy; Klaus B Simonsen; Dionisios Vourloumis; Sarah Fish; Jamie M Froelich; Daniel Wall; Thomas Hermann
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

6.  Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines.

Authors:  Yuefen Zhou; Zhongxiang Sun; Jamie M Froelich; Thomas Hermann; Daniel Wall
Journal:  Bioorg Med Chem Lett       Date:  2006-08-04       Impact factor: 2.823

Review 7.  Protein binding and its significance in antibacterial therapy.

Authors:  W A Craig; S C Ebert
Journal:  Infect Dis Clin North Am       Date:  1989-09       Impact factor: 5.982

Review 8.  Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures.

Authors:  Quentin Vicens; Eric Westhof
Journal:  Biopolymers       Date:  2003-09       Impact factor: 2.505

9.  Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome.

Authors:  Sofia Barluenga; Klaus B Simonsen; Ethel S Littlefield; Benjamin K Ayida; Dionisios Vourloumis; Geoffrey C Winters; Masayuki Takahashi; Sarah Shandrick; Qiang Zhao; Qing Han; Thomas Hermann
Journal:  Bioorg Med Chem Lett       Date:  2004-02-09       Impact factor: 2.823

10.  The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures.

Authors:  Peter Pfister; Sven Hobbie; Quentin Vicens; Erik C Böttger; Eric Westhof
Journal:  Chembiochem       Date:  2003-10-06       Impact factor: 3.164
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  1 in total

1.  Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics.

Authors:  Maruthi Chittapragada; Sarah Roberts; Young Wan Ham
Journal:  Perspect Medicin Chem       Date:  2009-04-28
  1 in total

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