BACKGROUND: The outcome of patients with non-extremity synovial sarcoma (SS) is generally worse than that of patients with limb tumours. METHODS: The present study analysed a series of 115 consecutive SS patients treated in Italian paediatric protocols (period 1979-2005), mainly focusing on the 30 cases arising from 'axial' sites (16 head-neck, 8 trunk, 4 lung-pleura and 2 retroperitoneum). RESULTS: Initial gross resection was achieved in 40% of axial cases and in 80% of limb SS (p<0.0001). Five-year EFS and overall survival (OS) were, respectively, 43.3% and 55.1% for axial SS, and 69.6% (p=0.0068) and 84.0% (p=0.0004) for extremity SS. Local progression/recurrence was the cause of treatment failure in 75% of relapsing patients axial disease. CONCLUSIONS: Our findings emphasise that children and adolescents with SS originating at non-extremity locations have a worse prognosis than those with limb SS. Tumour site should be considered when defining a risk-adapted treatment strategy for SS.
BACKGROUND: The outcome of patients with non-extremity synovial sarcoma (SS) is generally worse than that of patients with limb tumours. METHODS: The present study analysed a series of 115 consecutive SS patients treated in Italian paediatric protocols (period 1979-2005), mainly focusing on the 30 cases arising from 'axial' sites (16 head-neck, 8 trunk, 4 lung-pleura and 2 retroperitoneum). RESULTS: Initial gross resection was achieved in 40% of axial cases and in 80% of limb SS (p<0.0001). Five-year EFS and overall survival (OS) were, respectively, 43.3% and 55.1% for axial SS, and 69.6% (p=0.0068) and 84.0% (p=0.0004) for extremity SS. Local progression/recurrence was the cause of treatment failure in 75% of relapsing patientsaxial disease. CONCLUSIONS: Our findings emphasise that children and adolescents with SS originating at non-extremity locations have a worse prognosis than those with limb SS. Tumour site should be considered when defining a risk-adapted treatment strategy for SS.
Authors: Bernhard M Speth; Andreas H Krieg; Andre Kaelin; G Ulrich Exner; Louis Guillou; Arthur von Hochstetter; Gernot Jundt; Fritz Hefti Journal: J Child Orthop Date: 2011-08-11 Impact factor: 1.548
Authors: Andrea Ferrari; Rosalba Miceli; Annie Rey; Odile Oberlin; Daniel Orbach; Bernadette Brennan; Luigi Mariani; Modesto Carli; Gianni Bisogno; Giovanni Cecchetto; Gian Luca De Salvo; Michela Casanova; Max M Vannoesel; Anna Kelsey; Michael C Stevens; Meenakshi Devidas; Alberto S Pappo; Sheri L Spunt Journal: Eur J Cancer Date: 2010-12-08 Impact factor: 9.162
Authors: Andrea Ferrari; Yueh-Yun Chi; Gian Luca De Salvo; Daniel Orbach; Bernadette Brennan; R Lor Randall; M Beth McCarville; Jennifer O Black; Rita Alaggio; Douglas S Hawkins; Gianni Bisogno; Sheri L Spunt Journal: Eur J Cancer Date: 2017-04-07 Impact factor: 9.162
Authors: Matthew J Krasin; Andrew M Davidoff; Xiaoping Xiong; Shengjie Wu; Chia-Ho Hua; Fariba Navid; Carlos Rodriguez-Galindo; Bhaskar N Rao; Kelly A Hoth; Michael D Neel; Thomas E Merchant; Larry E Kun; Sheri L Spunt Journal: Int J Radiat Oncol Biol Phys Date: 2009-07-20 Impact factor: 7.038