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Literature DB >> 18440087

Gene expression profiling of non-small cell lung cancer.

Sunil Singhal¹, Daniel Miller, Suresh Ramalingam, Shi-Yong Sun.

Abstract

Functional genomics has emerged over the past 10 years as a novel technology to study genetic alterations. Gene expression arrays are one genomic technique employed to discover changes in the DNA expression that occur in neoplastic transformation. Microarrays have been applied to investigating lung cancer. Specific applications include discovering novel genetic changes that occur in lung tumors. Microarrays can also be applied to improve diagnosis, staging and discover prognostic markers. The eventual goal of this technology is to discover new markers for therapy and to customize therapy based on an individual tumor genetic composition. In this review, we present the current state of gene expression array technology in its application to lung cancer.

Entities: Disease

Mesh：

Substances：
Biomarkers, Tumor

Year: 2008 PMID： 18440087 PMCID： PMC2517078 DOI： 10.1016/j.lungcan.2008.03.007

Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705

56 in total

1. Microarray data simulator for improved selection of differentially expressed genes.

Authors: Sunil Singhal; Chris G Kyvernitis; Steven W Johnson; Larry R Kaiser; Michael N Liebman; Steven M Albelda
Journal: Cancer Biol Ther Date: 2003 Jul-Aug Impact factor: 4.742

2. LKB1 modulates lung cancer differentiation and metastasis.

Authors: Hongbin Ji; Matthew R Ramsey; D Neil Hayes; Cheng Fan; Kate McNamara; Piotr Kozlowski; Chad Torrice; Michael C Wu; Takeshi Shimamura; Samanthi A Perera; Mei-Chih Liang; Dongpo Cai; George N Naumov; Lei Bao; Cristina M Contreras; Danan Li; Liang Chen; Janakiraman Krishnamurthy; Jussi Koivunen; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Neal I Lindeman; David C Christiani; Xihong Lin; Geoffrey I Shapiro; Pasi A Jänne; Bruce E Johnson; Matthew Meyerson; David J Kwiatkowski; Diego H Castrillon; Nabeel Bardeesy; Norman E Sharpless; Kwok-Kin Wong
Journal: Nature Date: 2007-08-05 Impact factor: 49.962

Review 3. How to improve reliability and efficiency of research about molecular markers: roles of phases, guidelines, and study design.

Authors: David F Ransohoff
Journal: J Clin Epidemiol Date: 2007-09-24 Impact factor: 6.437

4. Overexpression of phosphatidylinositol 3-kinase in human lung cancer.

Authors: X Lin; A S Böhle; P Dohrmann; I Leuschner; A Schulz; B Kremer; F Fändrich
Journal: Langenbecks Arch Surg Date: 2001-07 Impact factor: 3.445

5. Diagnostic usefulness of tumour marker levels in pleural effusions of malignant and benign origin.

Authors: F Kuralay; Z Tokgöz; A Cömlekci
Journal: Clin Chim Acta Date: 2000-10 Impact factor: 3.786

6. Prevalence and specificity of LKB1 genetic alterations in lung cancers.

Authors: S Matsumoto; R Iwakawa; K Takahashi; T Kohno; Y Nakanishi; Y Matsuno; K Suzuki; M Nakamoto; E Shimizu; J D Minna; J Yokota
Journal: Oncogene Date: 2007-03-26 Impact factor: 9.867

7. Characterizing the cancer genome in lung adenocarcinoma.

Authors: Barbara A Weir; Michele S Woo; Gad Getz; Sven Perner; Li Ding; Rameen Beroukhim; William M Lin; Michael A Province; Aldi Kraja; Laura A Johnson; Kinjal Shah; Mitsuo Sato; Roman K Thomas; Justine A Barletta; Ingrid B Borecki; Stephen Broderick; Andrew C Chang; Derek Y Chiang; Lucian R Chirieac; Jeonghee Cho; Yoshitaka Fujii; Adi F Gazdar; Thomas Giordano; Heidi Greulich; Megan Hanna; Bruce E Johnson; Mark G Kris; Alex Lash; Ling Lin; Neal Lindeman; Elaine R Mardis; John D McPherson; John D Minna; Margaret B Morgan; Mark Nadel; Mark B Orringer; John R Osborne; Brad Ozenberger; Alex H Ramos; James Robinson; Jack A Roth; Valerie Rusch; Hidefumi Sasaki; Frances Shepherd; Carrie Sougnez; Margaret R Spitz; Ming-Sound Tsao; David Twomey; Roel G W Verhaak; George M Weinstock; David A Wheeler; Wendy Winckler; Akihiko Yoshizawa; Soyoung Yu; Maureen F Zakowski; Qunyuan Zhang; David G Beer; Ignacio I Wistuba; Mark A Watson; Levi A Garraway; Marc Ladanyi; William D Travis; William Pao; Mark A Rubin; Stacey B Gabriel; Richard A Gibbs; Harold E Varmus; Richard K Wilson; Eric S Lander; Matthew Meyerson
Journal: Nature Date: 2007-11-04 Impact factor: 49.962

8. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.

Authors: Kentaro Inamura; Kengo Takeuchi; Yuki Togashi; Kimie Nomura; Hironori Ninomiya; Michiyo Okui; Yukitoshi Satoh; Sakae Okumura; Ken Nakagawa; Manabu Soda; Young Lim Choi; Toshiro Niki; Hiroyuki Mano; Yuichi Ishikawa
Journal: J Thorac Oncol Date: 2008-01 Impact factor: 15.609

9. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer.

Authors: K A Kwei; Y H Kim; L Girard; J Kao; M Pacyna-Gengelbach; K Salari; J Lee; Y-L Choi; M Sato; P Wang; T Hernandez-Boussard; A F Gazdar; I Petersen; J D Minna; J R Pollack
Journal: Oncogene Date: 2008-01-21 Impact factor: 9.867

10. A training-testing approach to the molecular classification of resected non-small cell lung cancer.

Authors: Noboru Yamagata; Yu Shyr; Kiyoshi Yanagisawa; Mary Edgerton; Thao P Dang; Adriana Gonzalez; Sorena Nadaf; Paul Larsen; John R Roberts; Jonathan C Nesbitt; Roy Jensen; Shawn Levy; Jason H Moore; John D Minna; David P Carbone
Journal: Clin Cancer Res Date: 2003-10-15 Impact factor: 12.531

26 in total

1. CXCL5 as a potential novel prognostic factor in early stage non-small cell lung cancer: results of a study of expression levels of 23 genes.

Authors: Oksana Kowalczuk; Tomasz Burzykowski; Wieslawa Ewa Niklinska; Miroslaw Kozlowski; Lech Chyczewski; Jacek Niklinski
Journal: Tumour Biol Date: 2014-02-06

10. Positive expression of ERCC1 predicts a poorer platinum-based treatment outcome in Chinese patients with advanced non-small-cell lung cancer.

Authors: Xin Wang; Jun Zhao; Lu Yang; Li Mao; Tongtong An; Hua Bai; Shuhang Wang; Xuyi Liu; Guoshuang Feng; Jie Wang
Journal: Med Oncol Date: 2009-06-02 Impact factor: 3.064

Gene expression profiling of non-small cell lung cancer.

1. Microarray data simulator for improved selection of differentially expressed genes.

2. LKB1 modulates lung cancer differentiation and metastasis.

Review 3. How to improve reliability and efficiency of research about molecular markers: roles of phases, guidelines, and study design.

4. Overexpression of phosphatidylinositol 3-kinase in human lung cancer.

5. Diagnostic usefulness of tumour marker levels in pleural effusions of malignant and benign origin.

6. Prevalence and specificity of LKB1 genetic alterations in lung cancers.

7. Characterizing the cancer genome in lung adenocarcinoma.

8. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.

9. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer.

10. A training-testing approach to the molecular classification of resected non-small cell lung cancer.

1. CXCL5 as a potential novel prognostic factor in early stage non-small cell lung cancer: results of a study of expression levels of 23 genes.

Review 2. Radiogenomics predicting tumor responses to radiotherapy in lung cancer.

3. Smoking-Related Gene Expression in Laser Capture-Microdissected Human Lung.

Review 4. Current status of research and treatment for non-small cell lung cancer in never-smoking females.

5. Identification of key genes and biological pathways in lung adenocarcinoma via bioinformatics analysis.

Review 6. Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases.

7. Expression profile based gene clusters for ischemic stroke detection.

Review 8. Integrating omics technologies to study pulmonary physiology and pathology at the systems level.

Review 9. Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis.

10. Positive expression of ERCC1 predicts a poorer platinum-based treatment outcome in Chinese patients with advanced non-small-cell lung cancer.