| Literature DB >> 18439927 |
J-P Azulay1, F Durif, R Rogez, C Tranchant, I Bourdeix, K Rerat.
Abstract
It has been known for more than 30 years that the efficiency of the dopaminergic treatments can wear off. Currently, motor fluctuations and especially non-motor fluctuations (dysautonomic, cognitive/psychiatric or sensory/pain) remain often underdiagnosed in the first years of treatment. The patient self-questionnaire used in this study has been developed and validated in the United States. Its French version has been tested in daily practice in a study with 938 Parkinson's patients followed-up by movement disorders specialists. Use of this self-assessment patient card has resulted in the detection of fluctuations in 49% of patients, considered nonfluctuating by neurologists after a clinical assessment. The impact of these fluctuations unknown at first is significant, since these motor and/or non motor symptoms are considered troublesome or perturbing for daily life activities by 70% of fluctuating patients. The investigators have recognized the usefulness of this self-assessment in order to detect fluctuations in 81% of fluctuating patients, which lead them to modify the treatment in 76% of them.Entities:
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Year: 2008 PMID: 18439927 DOI: 10.1016/j.neurol.2008.01.003
Source DB: PubMed Journal: Rev Neurol (Paris) ISSN: 0035-3787 Impact factor: 2.607