| Literature DB >> 18439910 |
Jai-Hee Moon1, Byung Sun Yoon, Bona Kim, Gyuman Park, Hye-Youn Jung, Isaac Maeng, Eun Kyoung Jun, Seung Jun Yoo, Aeree Kim, Sejong Oh, Kwang Youn Whang, Hyunggee Kim, Dong-Wook Kim, Ki Dong Kim, Seungkwon You.
Abstract
Recently, Bmi1 was shown to control the proliferation and self-renewal of neural stem cells (NSCs). In this study, we demonstrated the induction of NSC-like cells (NSCLCs) from mouse astrocytes by Bmi1 under NSC culture conditions. These NSCLCs exhibited the morphology and growth properties of NSCs, and expressed NSC marker genes, including nestin, CD133, and Sox2. In vitro differentiation of NSCLCs resulted in differentiated cell populations containing astrocytes, neurons, and oligodendrocytes. Following treatment with histone deacetylase inhibitors (trichostatin A and valproic acid), the potential of NSCLCs for proliferation, dedifferentiation, and self-renewal was significantly inhibited. Our data indicate that multipotent NSCLCs can be generated directly from astrocytes by the addition of Bmi1.Entities:
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Year: 2008 PMID： 18439910 DOI： 10.1016/j.bbrc.2008.04.068
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575