BACKGROUND: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. CONCLUSIONS: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.
BACKGROUND: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. CONCLUSIONS: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTLDYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.
Authors: R D Todd; E R Rasmussen; R J Neuman; W Reich; J J Hudziak; K K Bucholz; P A Madden; A Heath Journal: Am J Psychiatry Date: 2001-11 Impact factor: 18.112
Authors: Simon E Fisher; Clyde Francks; James T McCracken; James J McGough; Angela J Marlow; I Laurence MacPhie; Dianne F Newbury; Lori R Crawford; Christina G S Palmer; J Arthur Woodward; Melissa Del'Homme; Dennis P Cantwell; Stanley F Nelson; Anthony P Monaco; Susan L Smalley Journal: Am J Hum Genet Date: 2002-03-28 Impact factor: 11.025
Authors: Mauricio Arcos-Burgos; F Xavier Castellanos; David Pineda; Francisco Lopera; Juan David Palacio; Luis Guillermo Palacio; Judith L Rapoport; Kate Berg; Joan E Bailey-Wilson; Maximilian Muenke Journal: Am J Hum Genet Date: 2004-10-20 Impact factor: 11.025
Authors: Wai Chen; Kaixin Zhou; Pak Sham; Barbara Franke; Jonna Kuntsi; Desmond Campbell; Karin Fleischman; Jo Knight; Penny Andreou; Renée Arnold; Marieke Altink; Frits Boer; Mary Jane Boholst; Cathelijne Buschgens; Louise Butler; Hanna Christiansen; Ellen Fliers; Raoul Howe-Forbes; Isabel Gabriëls; Alexander Heise; Isabelle Korn-Lubetzki; Rafaela Marco; She'era Medad; Ruud Minderaa; Ueli C Müller; Aisling Mulligan; Lamprini Psychogiou; Nanda Rommelse; Vaheshta Sethna; Henrik Uebel; Peter McGuffin; Robert Plomin; Tobias Banaschewski; Jan Buitelaar; Richard Ebstein; Jacques Eisenberg; Michael Gill; Iris Manor; Ana Miranda; Fernando Mulas; Robert D Oades; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Edmund Sonuga-Barke; Hans-Christoph Steinhausen; Eric Taylor; Margaret Thompson; Stephen V Faraone; Philip Asherson Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-12-05 Impact factor: 3.568
Authors: Benjamin M Neale; Sarah Medland; Stephan Ripke; Richard J L Anney; Philip Asherson; Jan Buitelaar; Barbara Franke; Michael Gill; Lindsey Kent; Peter Holmans; Frank Middleton; Anita Thapar; Klaus-Peter Lesch; Stephen V Faraone; Mark Daly; Thuy Trang Nguyen; Helmut Schäfer; Hans-Christoph Steinhausen; Andreas Reif; Tobias J Renner; Marcel Romanos; Jasmin Romanos; Andreas Warnke; Susanne Walitza; Christine Freitag; Jobst Meyer; Haukur Palmason; Aribert Rothenberger; Ziarih Hawi; Joseph Sergeant; Herbert Roeyers; Eric Mick; Joseph Biederman Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-08-05 Impact factor: 8.829
Authors: Judith S Nijmeijer; Alejandro Arias-Vásquez; Nanda N J Rommelse; Marieke E Altink; Richard J L Anney; Philip Asherson; Tobias Banaschewski; Cathelijne J M Buschgens; Ellen A Fliers; Michael Gill; Ruud B Minderaa; Luise Poustka; Joseph A Sergeant; Jan K Buitelaar; Barbara Franke; Richard P Ebstein; Ana Miranda; Fernando Mulas; Robert D Oades; Herbert Roeyers; Aribert Rothenberger; Edmund J S Sonuga-Barke; Hans-Christoph Steinhausen; Stephen V Faraone; Catharina A Hartman; Pieter J Hoekstra Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-05-20 Impact factor: 8.829
Authors: Nanda N J Rommelse; Alejandro Arias-Vásquez; Marieke E Altink; Cathelijne J M Buschgens; Ellen Fliers; Philip Asherson; Stephen V Faraone; Jan K Buitelaar; Joseph A Sergeant; Jaap Oosterlaan; Barbara Franke Journal: Am J Hum Genet Date: 2008-07 Impact factor: 11.025
Authors: Lauren Micalizzi; Leslie A Brick; Marisa E Marraccini; Chelsie E Benca-Bachman; Rohan H C Palmer; Valerie S Knopik Journal: Dev Psychopathol Date: 2021-02
Authors: Judith S Nijmeijer; Alejandro Arias-Vásquez; Nanda N J Rommelse; Marieke E Altink; Cathelijne J M Buschgens; Ellen A Fliers; Barbara Franke; Ruud B Minderaa; Joseph A Sergeant; Jan K Buitelaar; Pieter J Hoekstra; Catharina A Hartman Journal: J Autism Dev Disord Date: 2014-07
Authors: Benjamin M Neale; Jessica Lasky-Su; Richard Anney; Barbara Franke; Kaixin Zhou; Julian B Maller; Alejandro Arias Vasquez; Philip Asherson; Wai Chen; Tobias Banaschewski; Jan Buitelaar; Richard Ebstein; Michael Gill; Ana Miranda; Robert D Oades; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Hans Christoph Steinhausen; Edmund Sonuga-Barke; Fernando Mulas; Eric Taylor; Nan Laird; Christoph Lange; Mark Daly; Stephen V Faraone Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-12-05 Impact factor: 3.568
Authors: Daniel von Rhein; Maarten Mennes; Hanneke van Ewijk; Annabeth P Groenman; Marcel P Zwiers; Jaap Oosterlaan; Dirk Heslenfeld; Barbara Franke; Pieter J Hoekstra; Stephen V Faraone; Catharina Hartman; Jan Buitelaar Journal: Eur Child Adolesc Psychiatry Date: 2014-07-11 Impact factor: 4.785
Authors: Najaf Amin; Yuri S Aulchenko; Marieke C Dekker; Robert F Ferdinand; Alwin van Spreeken; Alfons H Temmink; Frank C Verhulst; Ben A Oostra; Cornelia M van Duijn Journal: Eur J Hum Genet Date: 2009-01-21 Impact factor: 4.246