O Torkildsen1, L A Brunborg, K-M Myhr, L Bø. 1. Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway. oivind.torkildsen@gmail.com
Abstract
BACKGROUND: Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone. MATERIALS AND METHODS: This article reviews previous research on this model and discusses the potential of the model for future application in MS research. DISCUSSION: The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de- and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice.
BACKGROUND: Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone. MATERIALS AND METHODS: This article reviews previous research on this model and discusses the potential of the model for future application in MS research. DISCUSSION: The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de- and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice.
Authors: Filomena Mattner; David Linares Bandin; Maria Staykova; Paula Berghofer; Marie Claude Gregoire; Patrice Ballantyne; Mitchell Quinlivan; Susan Fordham; Tien Pham; David O Willenborg; Andrew Katsifis Journal: Eur J Nucl Med Mol Imaging Date: 2011-04-12 Impact factor: 9.236
Authors: Steven M Wellman; Kelly Guzman; Kevin C Stieger; Lauren E Brink; Sadhana Sridhar; Mitchell T Dubaniewicz; Lehong Li; Franca Cambi; Takashi D Y Kozai Journal: Biomaterials Date: 2020-02-06 Impact factor: 12.479