Donald W Black1, Martha C Shaw, Jeff Allen. 1. University of Iowa Roy J. and Lucille A. Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA. donald-black@uiowa.edu
Abstract
BACKGROUND: The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG). METHOD: Non-depressed outpatients with DSM-IV PG received flexibly dosed extended release carbamazepine in a prospective 10-week open-label trial following a two-week observation period. Subjects were evaluated at baseline and at one week intervals during a four week titration period, and every two weeks thereafter for assessment of gambling behavior, mood, and adverse experiences. The primary efficacy measure was the Yale-Brown Obsessive-Compulsive Scale modified for PG (YBOCS-PG). RESULTS: Eight subjects (6 men, 2 women) had at least one post-baseline visit, and five subjects (63%) completed the protocol. Significant improvement was found on the YBOCS-PG (P< .001). Seven of the eight subjects with post-baseline assessment (88%) were considered responders (i.e., achieved "much" or "very much" improvement on the CGI). Four subjects (50%) abstained from gambling during their final month of study participation. Several patients were dropped because of adverse experiences. CONCLUSION: The results suggest that extended release carbamazepine may be effective in the treatment of PG.
BACKGROUND: The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG). METHOD:Non-depressed outpatients with DSM-IV PG received flexibly dosed extended release carbamazepine in a prospective 10-week open-label trial following a two-week observation period. Subjects were evaluated at baseline and at one week intervals during a four week titration period, and every two weeks thereafter for assessment of gambling behavior, mood, and adverse experiences. The primary efficacy measure was the Yale-Brown Obsessive-Compulsive Scale modified for PG (YBOCS-PG). RESULTS: Eight subjects (6 men, 2 women) had at least one post-baseline visit, and five subjects (63%) completed the protocol. Significant improvement was found on the YBOCS-PG (P< .001). Seven of the eight subjects with post-baseline assessment (88%) were considered responders (i.e., achieved "much" or "very much" improvement on the CGI). Four subjects (50%) abstained from gambling during their final month of study participation. Several patients were dropped because of adverse experiences. CONCLUSION: The results suggest that extended release carbamazepine may be effective in the treatment of PG.
Authors: Jon E Grant; Samuel R Chamberlain; Brian L Odlaug; Marc N Potenza; Suck Won Kim Journal: Psychopharmacology (Berl) Date: 2010-08-19 Impact factor: 4.530
Authors: Donald Wayne Black; Martha Shaw; Brett McCormick; John David Bayless; Jeff Allen Journal: Psychiatry Res Date: 2012-07-04 Impact factor: 3.222
Authors: Matteo Lupi; Giovanni Martinotti; Tiziano Acciavatti; Mauro Pettorruso; Marcella Brunetti; Rita Santacroce; Eduardo Cinosi; Giuseppe Di Iorio; Marco Di Nicola; Massimo Di Giannantonio Journal: Biomed Res Int Date: 2014-05-18 Impact factor: 3.411