| Literature DB >> 18436344 |
E van der Merwe1, D Huang, D Peterson, G Kilian, P J Milne, M Van de Venter, C Frost.
Abstract
Six selected diketopiperazines, cyclo(Gly-Val), cyclo(Gly-D-Val), cyclo(Gly-Leu), cyclo(Gly-Ile), cyclo(Phe-Cys) and cyclo(Tyr-Cys), were synthesized via various synthetic routes. Their potential to inhibit cancer cell growth in HT-29, HeLa and MCF-7 cells was determined. Cyclo(Tyr-Cys) caused the greatest inhibition in cervical carcinoma cells with near equivalent activity against HT-29 and MCF-7 cells. The other cyclic dipeptides tested were effective in the inhibition of colon, cervical and breast carcinoma cells, respectively, but the percentage inhibition was lower than for cyclo(Tyr-Cys).Entities:
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Year: 2008 PMID： 18436344 DOI： 10.1016/j.peptides.2008.03.010
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750