BACKGROUND: Commercially available sugar-free chewing gums have been claimed to provide oral health benefits. AIM: The aim of this randomized, double-blind crossover in situ study was to compare the efficacy of three commercially available sugar-free chewing gums: Trident White, Orbit, and Orbit Professional, in remineralizing enamel subsurface lesions in situ. DESIGN:Specimens containing enamel subsurface lesions were sectioned into test and control half-slabs with the test half-slabs inserted into removable palatal appliances. For each test chewing period, subjects were randomly allocated one of three test gums. Subjects (n = 10) chewed the randomly allocated gum for a 20-min period four times per day for 14 days. Each subject chewed all three test gums, with a 7-day washout period between crossovers. After each 14-day cycle, test and control half-slabs were paired, embedded in resin, sectioned, and subjected to microradiography to determine remineralization. RESULTS: The gum TW produced significantly greater remineralization (18.4 +/- 0.9%) than Orbit (8.9 +/- 0.5%) and Orbit Professional (10.5 +/- 0.9%). CONCLUSION: The superior remineralization activity of the TW gum in situ was attributed to the presence of casein phosphopeptide-amorphous calcium phosphate nanocomplexes.
RCT Entities:
BACKGROUND: Commercially available sugar-free chewing gums have been claimed to provide oral health benefits. AIM: The aim of this randomized, double-blind crossover in situ study was to compare the efficacy of three commercially available sugar-free chewing gums: Trident White, Orbit, and Orbit Professional, in remineralizing enamel subsurface lesions in situ. DESIGN: Specimens containing enamel subsurface lesions were sectioned into test and control half-slabs with the test half-slabs inserted into removable palatal appliances. For each test chewing period, subjects were randomly allocated one of three test gums. Subjects (n = 10) chewed the randomly allocated gum for a 20-min period four times per day for 14 days. Each subject chewed all three test gums, with a 7-day washout period between crossovers. After each 14-day cycle, test and control half-slabs were paired, embedded in resin, sectioned, and subjected to microradiography to determine remineralization. RESULTS: The gum TW produced significantly greater remineralization (18.4 +/- 0.9%) than Orbit (8.9 +/- 0.5%) and Orbit Professional (10.5 +/- 0.9%). CONCLUSION: The superior remineralization activity of the TW gum in situ was attributed to the presence of casein phosphopeptide-amorphous calcium phosphate nanocomplexes.
Authors: Christina P C Sim; Joseph Wee; Ying Xu; Yin-Bun Cheung; Yoke-Lim Soong; David J Manton Journal: Clin Oral Investig Date: 2014-09-27 Impact factor: 3.573
Authors: Peter Rechmann; Sona Bekmezian; Beate M T Rechmann; Benjamin W Chaffee; John D B Featherstone Journal: Clin Oral Investig Date: 2018-01-04 Impact factor: 3.573
Authors: Greg J Huang; Brie Roloff-Chiang; Brian E Mills; Salma Shalchi; Charles Spiekerman; Anna M Korpak; Jeri L Starrett; Geoffrey M Greenlee; Ross J Drangsholt; Jack C Matunas Journal: Am J Orthod Dentofacial Orthop Date: 2013-01 Impact factor: 2.650