Literature DB >> 18434967

Gardos pathway to sickle cell therapies?

Clinton H Joiner1.   

Abstract

In this issue of Blood, Ataga and colleagues report that treatment of sickle cell disease patients with senicapoc, a Gardos channel inhibitor, reduces the number of dehydrated cells, increases hemoglobin levels, and diminishes hemolysis.

Entities:  

Year:  2008        PMID： 18434967      PMCID： PMC2288713          DOI： 10.1182/blood-2008-01-135350

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  8 in total

1.  The function of calcium in the potassium permeability of human erythrocytes.

Authors:  G GARDOS
Journal:  Biochim Biophys Acta       Date:  1958-12

2.  Potassium and sodium of red blood cells in sickle cell anemia.

Authors:  D C TOSTESON; E SHEA; R C DARLING
Journal:  J Clin Invest       Date:  1952-04       Impact factor: 14.808

3.  The irreversibly sickled cell; a determinant of haemolysis in sickle cell anaemia.

Authors:  G R Serjeant; B E Serjeant; P F Milner
Journal:  Br J Haematol       Date:  1969-12       Impact factor: 6.998

4.  Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes.

Authors:  Clinton H Joiner; R Kirk Rettig; Maorong Jiang; Mary Risinger; Robert S Franco
Journal:  Blood       Date:  2006-10-05       Impact factor: 22.113

5.  Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells.

Authors:  S K Ballas
Journal:  Am J Hematol       Date:  1991-02       Impact factor: 10.047

Review 6.  Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.

Authors:  Gregory J Kato; Mark T Gladwin; Martin H Steinberg
Journal:  Blood Rev       Date:  2006-11-07       Impact factor: 8.250

7.  Dehydration response of sickle cells to sickling-induced Ca(++) permeabilization.

Authors:  Virgilio L Lew; Zipora Etzion; Robert M Bookchin
Journal:  Blood       Date:  2002-04-01       Impact factor: 22.113

8.  Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.

Authors:  C Brugnara; L de Franceschi; S L Alper
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808
  8 in total
  6 in total

1.  Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics.

Authors:  Stephanie M Knowlton; Bekir Yenilmez; Reza Amin; Savas Tasoglu
Journal:  J Vis Exp       Date:  2017-02-19       Impact factor: 1.355

Review 2.  Disorders of erythrocyte hydration.

Authors:  Patrick G Gallagher
Journal:  Blood       Date:  2017-10-19       Impact factor: 22.113

Review 3.  Blood rheology biomarkers in sickle cell disease.

Authors:  Madeleine Lu; Minke Ae Rab; Sergey S Shevkoplyas; Vivien A Sheehan
Journal:  Exp Biol Med (Maywood)       Date:  2020-01-16

4.  Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis.

Authors:  Ryan Zarychanski; Vincent P Schulz; Brett L Houston; Yelena Maksimova; Donald S Houston; Brian Smith; Jesse Rinehart; Patrick G Gallagher
Journal:  Blood       Date:  2012-04-23       Impact factor: 22.113

5.  Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis.

Authors:  Edyta Glogowska; Kimberly Lezon-Geyda; Yelena Maksimova; Vincent P Schulz; Patrick G Gallagher
Journal:  Blood       Date:  2015-07-21       Impact factor: 22.113

6.  Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

Authors:  David H Vandorpe; Chang Xu; Boris E Shmukler; Leo E Otterbein; Marie Trudel; Frederick Sachs; Philip A Gottlieb; Carlo Brugnara; Seth L Alper
Journal:  PLoS One       Date:  2010-01-15       Impact factor: 3.240
  6 in total

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