OBJECTIVE: Studies investigating the effects of depression on mortality following myocardial infarction (MI) have produced heterogeneous findings. We report on a study investigating whether the timing of the onset of depression, with regard to the MI, affected its impact on subsequent cardiac mortality. METHODS: Five hundred and eighty-eight subjects admitted following MI underwent assessments of cardiac status, cardiac risk factors, and noncardiac illness. We identified separately subjects who were depressed before their MI (pre-MI depression) and those who developed depression in the 12 months after MI (new-onset depression), using a standardized questionnaire and a research interview. Patients dying of cardiac cause were identified during 8-year follow-up using information from death certificates. RESULTS: Multivariate predictors of cardiac death during follow-up included: greater age (hazards ratio (HR) = 1.06, p = .007), previous angina (HR = 4.15, p < .0005), high Killip Class (HR = 2.21, p = .013), prescription of beta-blockers on discharge (HR = 0.37, p = .02), and new-onset depression (HR = 2.33, p = .038). Pre-MI depression did not convey any additional risk of cardiac mortality. CONCLUSION: We have shown increased cardiac mortality in patients who develop depression after suffering MI. Further observational studies need to separate pre- and post-MI depression if we are to determine underlying mechanisms by which depression is associated with mortality following MI.
OBJECTIVE: Studies investigating the effects of depression on mortality following myocardial infarction (MI) have produced heterogeneous findings. We report on a study investigating whether the timing of the onset of depression, with regard to the MI, affected its impact on subsequent cardiac mortality. METHODS: Five hundred and eighty-eight subjects admitted following MI underwent assessments of cardiac status, cardiac risk factors, and noncardiac illness. We identified separately subjects who were depressed before their MI (pre-MI depression) and those who developed depression in the 12 months after MI (new-onset depression), using a standardized questionnaire and a research interview. Patients dying of cardiac cause were identified during 8-year follow-up using information from death certificates. RESULTS: Multivariate predictors of cardiac death during follow-up included: greater age (hazards ratio (HR) = 1.06, p = .007), previous angina (HR = 4.15, p < .0005), high Killip Class (HR = 2.21, p = .013), prescription of beta-blockers on discharge (HR = 0.37, p = .02), and new-onset depression (HR = 2.33, p = .038). Pre-MI depression did not convey any additional risk of cardiac mortality. CONCLUSION: We have shown increased cardiac mortality in patients who develop depression after suffering MI. Further observational studies need to separate pre- and post-MI depression if we are to determine underlying mechanisms by which depression is associated with mortality following MI.
Authors: Thomas Sheeran; Catherine F Reilly; Patrick J Raue; Mark I Weinberger; Judith Pomerantz; Martha L Bruce Journal: Home Healthc Nurse Date: 2010-02
Authors: Radboud M Marijnissen; Lonneke Wouts; Robert A Schoevers; Marijke A Bremmer; Aartjan T F Beekman; Hannie C Comijs; Richard C Oude Voshaar Journal: Neurology Date: 2014-10-01 Impact factor: 9.910
Authors: Keerat Grewal; Donna E Stewart; Susan E Abbey; Yvonne W Leung; Jane Irvine; Sherry L Grace Journal: Psychosomatics Date: 2010 Jul-Aug Impact factor: 2.386
Authors: Yvonne W Leung; David B Flora; Shannon Gravely; Jane Irvine; Robert M Carney; Sherry L Grace Journal: Psychosom Med Date: 2012-09-21 Impact factor: 4.312
Authors: Viola Vaccarino; John Votaw; Tracy Faber; Emir Veledar; Nancy V Murrah; Linda R Jones; Jinying Zhao; Shaoyong Su; Jack Goldberg; J Paolo Raggi; Arshed A Quyyumi; David S Sheps; J Douglas Bremner Journal: Arch Intern Med Date: 2009-10-12