| Literature DB >> 18434143 |
Susan D Aster1, Donald W Graham, Divya Kharbanda, Gool Patel, Mitree Ponpipom, Gina M Santorelli, Michael J Szymonifka, Steven S Mundt, Kashmira Shah, Marty S Springer, Rolf Thieringer, Anne Hermanowski-Vosatka, Samuel D Wright, Jianying Xiao, Hratch Zokian, James M Balkovec.
Abstract
3-Aryl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They are active in both in vitro and an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.Entities:
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Year: 2008 PMID： 18434143 DOI： 10.1016/j.bmcl.2008.04.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823