Literature DB >> 18433937

Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease.

Ludovica Segat1, Michele Milanese, Beatrice Arosio, Carlo Vergani, Sergio Crovella.   

Abstract

In our case-control study we analyzed two functional IL18 gene promoter polymorphisms (-137G/C and -607C/A) and an additional polymorphism at position -656 (G/T) in Alzheimer patients and healthy controls in order to verify the involvement of these genetic variations in the onset of Alzheimer disease. No significant differences were detected for the three IL18 SNPs between AD patients and controls. The haplotypes distribution also did not show any difference within AD subjects and controls.

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Year:  2008        PMID: 18433937     DOI: 10.1016/j.neurobiolaging.2008.03.005

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN: 0197-4580            Impact factor:   4.673


  6 in total

1.  A gene-disease association study of IL18 in thyroid cancer: genotype and haplotype analyses.

Authors:  Farzan Abdolahi; Mohammad Hossein Dabbaghmanesh; Mohammad Reza Haghshenas; Abbas Ghaderi; Nasrollah Erfani
Journal:  Endocrine       Date:  2015-06-04       Impact factor: 3.633

Review 2.  The Role of Neuronal NLRP1 Inflammasome in Alzheimer's Disease: Bringing Neurons into the Neuroinflammation Game.

Authors:  Jeremy Kean Yi Yap; Benjamin Simon Pickard; Elaine Wan Ling Chan; Sook Yee Gan
Journal:  Mol Neurobiol       Date:  2019-05-20       Impact factor: 5.590

3.  Interleukin-18 -137 G/C and -607 C/A polymorphisms and Alzheimer's disease risk: a meta-analysis.

Authors:  Jiaojiao Zhang; Tingting Song; Hua Liang; Jie Lian; Guanjun Zhang; Huilin Gong
Journal:  Neurol Sci       Date:  2016-02-20       Impact factor: 3.307

Review 4.  Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms.

Authors:  Fan Su; Feng Bai; Zhijun Zhang
Journal:  Neurosci Bull       Date:  2016-08-27       Impact factor: 5.203

Review 5.  Interleukin 18 in the CNS.

Authors:  Silvia Alboni; Davide Cervia; Shuei Sugama; Bruno Conti
Journal:  J Neuroinflammation       Date:  2010-01-29       Impact factor: 8.322

6.  Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells.

Authors:  Elina M Sutinen; Tuula Pirttilä; George Anderson; Antero Salminen; Johanna O Ojala
Journal:  J Neuroinflammation       Date:  2012-08-16       Impact factor: 8.322

  6 in total

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