Literature DB >> 18433695

Spectrum of pleiotropic effects of statins in heart failure.

Nitin Mathur1, Kumudha Ramasubbu, Douglas L Mann.   

Abstract

The syndrome of heart failure is characterized by increased levels of circulating inflammatory mediators, which have been implicated in the pathogenesis of heart failure. Recently, a number of studies have suggested that statins may exert salutary effects in patients who have heart failure by virtue of their pleiotropic (non-lipid lowering) actions. This article focuses on the non-lipid lowering effects of statins, with an emphasis on the anti-inflammatory properties of these agents.

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Year:  2008        PMID： 18433695      PMCID： PMC2692470          DOI： 10.1016/j.hfc.2008.01.007

Source DB:  PubMed          Journal:  Heart Fail Clin        ISSN： 1551-7136            Impact factor:   3.179


  58 in total

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Journal:  Am J Pathol       Date:  1998-01       Impact factor: 4.307

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7.  Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.

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Journal:  J Biol Chem       Date:  1998-11-13       Impact factor: 5.157

8.  Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase.

Authors:  Ulf Landmesser; Niels Engberding; Ferdinand H Bahlmann; Arnd Schaefer; Antje Wiencke; Andre Heineke; Stephan Spiekermann; Denise Hilfiker-Kleiner; Christian Templin; Daniel Kotlarz; Maja Mueller; Martin Fuchs; Burkhard Hornig; Hermann Haller; Helmut Drexler
Journal:  Circulation       Date:  2004-10-05       Impact factor: 29.690

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Journal:  Hum Mutat       Date:  1992       Impact factor: 4.878

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Journal:  Circulation       Date:  1998-07-07       Impact factor: 29.690
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  6 in total

1.  Residual inflammatory risk after contemporary lipid lowering therapy.

Authors:  Haris Riaz; Safi U Khan; Noman Lateef; Swapna Talluri; Muhammad Shahzeb Khan; Milind Y Desai
Journal:  Eur Heart J Qual Care Clin Outcomes       Date:  2020-04-01

2.  Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells.

Authors:  Bianca Werner; Sven Dittmann; Carsten Funke; Klaus Überla; Cornelia Piper; Karsten Niehaus; Dieter Horstkotte; Martin Farr
Journal:  Inflamm Res       Date:  2013-12-08       Impact factor: 4.575

3.  Effect of atorvastatin in patients with chronic heart failure - insights from randomized clinical trials.

Authors:  Minwen Xu; Gaohui Yuan; Fanping Wei
Journal:  Arch Med Sci       Date:  2010-12-29       Impact factor: 3.318

Review 4.  Pleiotropic effects of statins.

Authors:  Narasaraju Kavalipati; Jay Shah; Ananthraman Ramakrishan; Hardik Vasnawala
Journal:  Indian J Endocrinol Metab       Date:  2015 Sep-Oct

5.  Profiling Heparin-Induced Thrombocytopenia (HIT) Antibodies in Hospitalized Patients With and Without Diabetes.

Authors:  Margaret Prechel; Susan Hudec; Elizabeth Lowden; Vicki Escalante; Nicholas Emanuele; Maryann Emanuele; Jeanine M Walenga
Journal:  Clin Appl Thromb Hemost       Date:  2018-11-12       Impact factor: 2.389

6.  Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study.

Authors:  Takuya Oikawa; Yasuhiko Sakata; Kotaro Nochioka; Masanobu Miura; Kanako Tsuji; Takeo Onose; Ruri Abe; Shintaro Kasahara; Masayuki Sato; Takashi Shiroto; Jun Takahashi; Satoshi Miyata; Hiroaki Shimokawa
Journal:  J Am Heart Assoc       Date:  2018-03-14       Impact factor: 5.501
  6 in total

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