| Literature DB >> 1843272 |
N Nakamura1, Y Tsutsumi, S Kimata, M Sawada, G Hasegawa, Y Kitagawa, K Nakano, M Kondo, H Nakao, S Makino.
Abstract
To determine whether environmental factors could affect the incidence of diabetes in RT6.1+ lymphocytes-depleted diabetes resistant (DR) BB rats, we tested polyinosinic-polycytidylic acid (Poly I:C), as an immune activator, in conjunction with anti-RT6.1 antibody in DR-BB rats which were bred in a specific pathogen free (SPF) condition. Diabetes was induced by the combined administration of poly I:C and anti-RT6.1 antibody. The use of poly I:C or anti-RT6.1 antibody alone did not cause diabetes. These results suggest that RT6.1+ T lymphocytes regulate autoimmune diabetes and that non-specific immune activation caused by environmental factors plays a key role in inducing diabetes in DR-BB rats.Entities:
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Year: 1991 PMID： 1843272 DOI： 10.1507/endocrj1954.38.523
Source DB: PubMed Journal: Endocrinol Jpn ISSN： 0013-7219