Literature DB >> 18432713

In vitro evaluation of experimental agents for anti-HIV activity.

D D Richman1, V A Johnson, D M Mayers, T Shirasaka, M C O'Brien, H Mitsuya.   

Abstract

This unit presents an assay that has proven useful as an initial screening test is an HIV cytopathic effect (CPE) inhibition assay in which immortalized T cell lines (e.g., ATH8 or MT2) that are profoundly sensitive to the cytopathic effect of certain strains of HIV are utilized as target cells. Additional protocols assess the anti-HIV activity of certain candidate agents by measuring inhibition of syncytium formation or p24 gag protein production by ELISA. Calculation of the 50% inhibitory concentration (IC(50)) is also presented.

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Year:  2001        PMID： 18432713     DOI： 10.1002/0471142735.im1209s08

Source DB:  PubMed          Journal:  Curr Protoc Immunol        ISSN： 1934-3671


  3 in total

1.  TRAF6 and IRF7 control HIV replication in macrophages.

Authors:  Mélissa Sirois; Lynda Robitaille; Robin Allary; Mohak Shah; Christopher H Woelk; Jérôme Estaquier; Jacques Corbeil
Journal:  PLoS One       Date:  2011-11-28       Impact factor: 3.240

2.  Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model.

Authors:  Silvana Pasetto; Vanessa Pardi; Ramiro Mendonça Murata
Journal:  PLoS One       Date:  2014-12-29       Impact factor: 3.240

3.  Dolabelladienols A-C, new diterpenes isolated from Brazilian brown alga Dictyota pfaffii.

Authors:  Alonso Pardo-Vargas; Ingrid de Barcelos Oliveira; Paulo Roberto Soares Stephens; Claudio Cesar Cirne-Santos; Izabel Christina Nunes de Palmer Paixão; Freddy Alejandro Ramos; Carlos Jiménez; Jaime Rodríguez; Jackson Antonio Lamounier Camargos Resende; Valeria Laneuville Teixeira; Leonardo Castellanos
Journal:  Mar Drugs       Date:  2014-07-23       Impact factor: 5.118
  3 in total

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