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Literature DB >> 18430938

Estimation of pairwise identity by descent from dense genetic marker data in a population sample of haplotypes.

Abstract

I present a new approach for calculating probabilities of identity by descent for pairs of haplotypes. The approach is based on a joint hidden Markov model for haplotype frequencies and identity by descent (IBD). This model allows for linkage disequilibrium, and the method can be applied to very dense marker data. The method has high power for detecting IBD tracts of genetic length of 1 cM, with the use of sufficiently dense markers. This enables detection of pairwise IBD between haplotypes from individuals whose most recent common ancestor lived up to 50 generations ago.

Mesh：

Substances：
Genetic Markers

Year: 2008 PMID： 18430938 PMCID： PMC2323802 DOI： 10.1534/genetics.107.084624

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

27 in total

1. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping.

Authors: M S McPeek; A Strahs
Journal: Am J Hum Genet Date: 1999-09 Impact factor: 11.025

Estimation of pairwise identity by descent from dense genetic marker data in a population sample of haplotypes.

1. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping.

2. On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit.

3. Estimation of the inbreeding coefficient through use of genomic data.

4. Haplotype sharing analysis using mantel statistics.

5. A model for the length of tracts of identity by descent in finite random mating populations.

6. Human evolution in Polynesia.

7. Relationship information contained in gamete identity by descent data.

8. Genomic mismatch scanning identifies human genomic DNA shared identical by descent.

9. Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.

10. Perspectives of identity by descent (IBD) mapping in founder populations.

1. Inferring coancestry in population samples in the presence of linkage disequilibrium.

2. Using identity by descent estimation with dense genotype data to detect positive selection.

3. High-resolution detection of identity by descent in unrelated individuals.

Review 4. Reconciling the analysis of IBD and IBS in complex trait studies.

Review 5. Identity by descent: variation in meiosis, across genomes, and in populations.

6. Deciphering the fine-structure of tribal admixture in the Bedouin population using genomic data.

7. A Fast and Simple Method for Detecting Identity-by-Descent Segments in Large-Scale Data.

8. A method for detecting IBD regions simultaneously in multiple individuals--with applications to disease genetics.

9. REFINING GENETICALLY INFERRED RELATIONSHIPS USING TREELET COVARIANCE SMOOTHING.

Review 10. Missing data imputation and haplotype phase inference for genome-wide association studies.