Literature DB >> 18430600

A compact linac for intensity modulated proton therapy based on a dielectric wall accelerator.

G J Caporaso1, T R Mackie, S Sampayan, Y-J Chen, D Blackfield, J Harris, S Hawkins, C Holmes, S Nelson, A Paul, B Poole, M Rhodes, D Sanders, J Sullivan, L Wang, J Watson, P J Reckwerdt, R Schmidt, D Pearson, R W Flynn, D Matthews, J Purdy.   

Abstract

A novel compact CT-guided intensity modulated proton radiotherapy (IMPT) system is described. The system is being designed to deliver fast IMPT so that larger target volumes and motion management can be accomplished. The system will be ideal for large and complex target volumes in young patients. The basis of the design is the dielectric wall accelerator (DWA) system being developed at the Lawrence Livermore National Laboratory (LLNL). The DWA uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. High electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The system will produce individual pulses that can be varied in intensity, energy and spot width. The IMPT planning system will optimize delivery characteristics. The system will be capable of being sited in a conventional linac vault and provide intensity modulated rotational therapy. Feasibility tests of an optimization system for selecting the position, energy, intensity and spot size for a collection of spots comprising the treatment are underway. A prototype is being designed and concept designs of the envelope and environmental needs of the unit are beginning. The status of the developmental new technologies that make the compact system possible will be reviewed. These include, high gradient vacuum insulators, solid dielectric materials, SiC photoconductive switches and compact proton sources.

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Year:  2008        PMID: 18430600     DOI: 10.1016/j.ejmp.2008.01.010

Source DB:  PubMed          Journal:  Phys Med        ISSN: 1120-1797            Impact factor:   2.685


  8 in total

Review 1.  Accelerator science in medical physics.

Authors:  K Peach; P Wilson; B Jones
Journal:  Br J Radiol       Date:  2011-12       Impact factor: 3.039

2.  Influence of robust optimization in intensity-modulated proton therapy with different dose delivery techniques.

Authors:  Wei Liu; Yupeng Li; Xiaoqiang Li; Wenhua Cao; Xiaodong Zhang
Journal:  Med Phys       Date:  2012-06       Impact factor: 4.071

3.  A gas scintillator detector for 2D dose profile monitoring in pencil beam scanning and pulsed beam proton radiotherapy treatments.

Authors:  S E Vigdor; A V Klyachko; K A Solberg; M Pankuch
Journal:  Phys Med Biol       Date:  2017-04-12       Impact factor: 3.609

4.  Risk of radiogenic second cancers following volumetric modulated arc therapy and proton arc therapy for prostate cancer.

Authors:  Laura A Rechner; Rebecca M Howell; Rui Zhang; Carol Etzel; Andrew K Lee; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2012-10-10       Impact factor: 3.609

Review 5.  The physics of proton therapy.

Authors:  Wayne D Newhauser; Rui Zhang
Journal:  Phys Med Biol       Date:  2015-03-24       Impact factor: 3.609

6.  Impact of margin size on the predicted risk of radiogenic second cancers following proton arc therapy and volumetric modulated arc therapy for prostate cancer.

Authors:  Laura A Rechner; Rebecca M Howell; Rui Zhang; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2012-11-15       Impact factor: 3.609

7.  Reducing the cost of proton radiation therapy: the feasibility of a streamlined treatment technique for prostate cancer.

Authors:  Wayne D Newhauser; Rui Zhang; Timothy G Jones; Annelise Giebeler; Phillip J Taddei; Robert D Stewart; Andrew Lee; Oleg Vassiliev
Journal:  Cancers (Basel)       Date:  2015-04-24       Impact factor: 6.639

8.  The energy margin strategy for reducing dose variation due to setup uncertainty in intensity modulated proton therapy (IMPT) delivered with distal edge tracking (DET).

Authors:  Miao Zhang; Ryan T Flynn; Xiaohu Mo; Thomas Rock Mackie
Journal:  J Appl Clin Med Phys       Date:  2012-09-06       Impact factor: 2.102

  8 in total

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