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Literature DB >> 184303

Natural immunity in mice to structural polypeptides of endogenous type C RNA viruses.

J R Stephenson, R L Peters, S Hino, R M Donahoe, L K Long, S A Aaronson, G J Kelloff.

Abstract

The immunological responses of inbred mice to structural components of one class of endogenous virus were investigated by means of radioimmunoassays utilizing highly purified viral proteins. Naturally occurring antiviral antibodies were demonstrated only in those strains possessing information for induction of a mouse cell-tropic endogenous virus. Moreover, these antibodies invariably appeared subsequent to the detection of spontaneous replication of this virus in the same animal. The immune responses elicited were much stronger against endogenous viral gp70 than p30, consistent with previous findings of tolerance in the mouse to the major structural antigen of its endogenous virus. However, the demonstration of an immune response to p30 under conditions of both natural and experimental immunization establishes that tolerance to this viral antigen can be overcome.

Entities: Gene Species

Mesh：

Substances：

Year: 1976 PMID： 184303 PMCID： PMC354929

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

25 in total

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors: F C GREENWOOD; W M HUNTER; J S GLOVER
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2. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses.

Authors: J W Hartley; W P Rowe
Journal: Virology Date: 1975-05 Impact factor: 3.616

3. Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.

Authors: J A Levy; J N Ihle; O Oleszko; R D Barnes
Journal: Proc Natl Acad Sci U S A Date: 1975-12 Impact factor: 11.205

4. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

5. Structural proteins of mammalian oncogenic RNA viruses: multiple antigenic determinants of the major internal protein and envelope glycoprotein.

Authors: M Strand; J T August
Journal: J Virol Date: 1974-01 Impact factor: 5.103

6. Localization of avian tumor virus group-specific antigen in cell and virus.

Authors: G Kelloff; P K Vogt
Journal: Virology Date: 1966-07 Impact factor: 3.616

7. Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus.

Authors: J R Stephenson; S R Tronick; S A Aaronson
Journal: Cell Date: 1974-12 Impact factor: 41.582

8. An approach to C-type virus immunoprevention of spontaneously occurring tumors in laboratory mice.

Authors: G J Kelloff; R L Peters; R M Donahoe; I Ghazzouli; B Sass; R M Nims; R J Huebner
Journal: Cancer Res Date: 1976-02 Impact factor: 12.701

9. Characterization of the type and group specificities of the immune response in mice to murine leukemia viruses.

Authors: J N Ihle; J J Domotor; K M Bengali
Journal: J Virol Date: 1976-04 Impact factor: 5.103

10. Correlation of early murine leukemia virus titer and H-2 type with spontaneous leukemia in mice of the BALB/c times AKR cross: a genetic analysis.

Authors: F Lilly; M L Duran-Reynals; W P Rowe
Journal: J Exp Med Date: 1975-04-01 Impact factor: 14.307

13 in total

1. Kinetics of retroviral production from the amphotropic ΨCRIP murine producer cell line.

Authors: B Q Shen; M F Clarke; B O Palsson
Journal: Cytotechnology Date: 1996-01 Impact factor: 2.058

2. Monoclonal antibody to the amino-terminal L sequence of murine leukemia virus glycosylated gag polyproteins demonstrates their unusual orientation in the cell membrane.

Authors: E A Pillemer; D A Kooistra; O N Witte; I L Weissman
Journal: J Virol Date: 1986-02 Impact factor: 5.103

6. Natural immunity in mice to the envelope glycoprotein of endogenous ecotropic type C viruses: neutralization of virus infectivity.

Authors: J N Ihle; B Lazar
Journal: J Virol Date: 1977-03 Impact factor: 5.103

10. The major internal protein, p27, of a retrovirus-like particle participates in immune complex formation in psoriasis.

Authors: O J Iversen; E Rødahl
Journal: Arch Virol Date: 1985 Impact factor: 2.574