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Literature DB >> 18429226

Introduction to peptide synthesis.

Abstract

A number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar-substitute aspartame to clinically used hormones, such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins, including their purification. It discusses selecting the solid support and common coupling reagents. Additional information is provided regarding common side reactions and synthesizing modified residues.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2002 PMID： 18429226 PMCID： PMC3564544 DOI： 10.1002/0471140864.ps1801s26

Source DB: PubMed Journal: Curr Protoc Protein Sci ISSN： 1934-3655

31 in total

Review 1. Current trends in the clinical development of peptide therapeutics.

Authors: Pauline M Saladin; Bodi D Zhang; Janice M Reichert
Journal: IDrugs Date: 2009-12

Review 2. Protein synthesis by chemical ligation of unprotected peptides in aqueous solution.

Authors: T W Muir; P E Dawson; S B Kent
Journal: Methods Enzymol Date: 1997 Impact factor: 1.600

Review 3. Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.

Authors: G B Fields; R L Noble
Journal: Int J Pept Protein Res Date: 1990-03

4. A chromatographic method for the quantitative analysis of the deprotection of dithiasuccinoyl (Dts) amino acids.

Authors: G Barany; R B Merrifield
Journal: Anal Biochem Date: 1979-05 Impact factor: 3.365

5. Solid phase peptide synthesis of 15N-gramicidins A, B, and C and high performance liquid chromatographic purification.

Authors: C G Fields; G B Fields; R L Noble; T A Cross
Journal: Int J Pept Protein Res Date: 1989-04

6. Fmoc/solid-phase synthesis of Tyr(P)-containing peptides through t-butyl phosphate protection.

Authors: J W Perich; E C Reynolds
Journal: Int J Pept Protein Res Date: 1991-06

7. Solid-phase synthesis of phosphopeptides.

Authors: L Otvos; I Elekes; V M Lee
Journal: Int J Pept Protein Res Date: 1989-08

8. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.

Authors: D S King; C G Fields; G B Fields
Journal: Int J Pept Protein Res Date: 1990-09

9. Synthesis of phosphotyrosyl-containing phosphopeptides by solid-phase peptide synthesis.

Authors: G Zardeneta; D L Chen; S T Weintraub; R J Klebe
Journal: Anal Biochem Date: 1990-11-01 Impact factor: 3.365

10. Coupling strategies in solid-phase synthesis of glycopeptides.

Authors: L Otvos; K Wroblewski; E Kollat; A Perczel; M Hollosi; G D Fasman; H C Ertl; J Thurin
Journal: Pept Res Date: 1989 Nov-Dec

8 in total

1. Recent Liquid Chromatographic Approaches and Developments for the Separation and Purification of Carbohydrates.

Authors: Gabe Nagy; Tianyuan Peng; Nicola L B Pohl
Journal: Anal Methods Date: 2017-05-24 Impact factor: 2.896

2. Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays.

Authors: Andrew N Hoofnagle; Jeffrey R Whiteaker; Steven A Carr; Eric Kuhn; Tao Liu; Sam A Massoni; Stefani N Thomas; R Reid Townsend; Lisa J Zimmerman; Emily Boja; Jing Chen; Daniel L Crimmins; Sherri R Davies; Yuqian Gao; Tara R Hiltke; Karen A Ketchum; Christopher R Kinsinger; Mehdi Mesri; Matthew R Meyer; Wei-Jun Qian; Regine M Schoenherr; Mitchell G Scott; Tujin Shi; Gordon R Whiteley; John A Wrobel; Chaochao Wu; Brad L Ackermann; Ruedi Aebersold; David R Barnidge; David M Bunk; Nigel Clarke; Jordan B Fishman; Russ P Grant; Ulrike Kusebauch; Mark M Kushnir; Mark S Lowenthal; Robert L Moritz; Hendrik Neubert; Scott D Patterson; Alan L Rockwood; John Rogers; Ravinder J Singh; Jennifer E Van Eyk; Steven H Wong; Shucha Zhang; Daniel W Chan; Xian Chen; Matthew J Ellis; Daniel C Liebler; Karin D Rodland; Henry Rodriguez; Richard D Smith; Zhen Zhang; Hui Zhang; Amanda G Paulovich
Journal: Clin Chem Date: 2016-01 Impact factor: 8.327

3. Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides.

Authors: Ruben Neves; Kailyn Stephens; Jillian E Smith-Carpenter
Journal: J Vis Exp Date: 2018-08-20 Impact factor: 1.355

4. Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography.

Authors: Gabe Nagy; Tianyuan Peng; Daniel E K Kabotso; Milos V Novotny; Nicola L B Pohl
Journal: Chem Commun (Camb) Date: 2016-11-03 Impact factor: 6.222

8. Short carboxyl terminal parathyroid hormone peptides modulate human parathyroid hormone signaling in mouse osteoblasts.

Authors: Kittrawee Kritmetapak; Ravinder J Singh; Theodore A Craig; Jolaine M Hines; Rajiv Kumar
Journal: Biochem Biophys Res Commun Date: 2021-07-28 Impact factor: 3.322