Literature DB >> 18428962

Synthesis of 2'-O-beta-d-Ribofuranosylnucleosides.

Sergey N Mikhailov1, Ekaterina V Efimtseva, Andrei A Rodionov, Georgii V Bobkov, Irina V Kulikova, Piet Herdewijn.   

Abstract

A simple and efficient method for the preparation of 2-O-beta-D-ribofuranosylnucleosides, minor tRNA components, is described in this unit. The method consists of condensation of a small excess of 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose activated with tin tetrachloride with N-protected 3,5-O-tetra-isopropyldisiloxane-1,3-diyl-ribonucleosides in 1,2-dichloroethane. Subsequent deprotection produces 2-O-beta-D-ribofuranosylnucleosides in an overall yield of 46% to 72%.

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Year:  2007        PMID： 18428962     DOI： 10.1002/0471142700.nc0114s27

Source DB:  PubMed          Journal:  Curr Protoc Nucleic Acid Chem        ISSN： 1934-9270


  2 in total

1.  In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.

Authors:  Nadezhda S Dyrkheeva; Irina A Chernyshova; Georgy A Ivanov; Yuri B Porozov; Anastasia A Zenchenko; Vladimir E Oslovsky; Alexandra L Zakharenko; Darina I Nasyrova; Galina N Likhatskaya; Sergey N Mikhailov; Olga I Lavrik; Mikhail S Drenichev
Journal:  Molecules       Date:  2022-04-09       Impact factor: 4.927

2.  Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides.

Authors:  Alexandra L Zakharenko; Mikhail S Drenichev; Nadezhda S Dyrkheeva; Georgy A Ivanov; Vladimir E Oslovsky; Ekaterina S Ilina; Irina A Chernyshova; Olga I Lavrik; Sergey N Mikhailov
Journal:  Molecules       Date:  2020-08-13       Impact factor: 4.411
  2 in total

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