Literature DB >> 18428571

Preclinical models to evaluate potential pharmacotherapeutic agents in treating alcoholism and studying the neuropharmacological bases of ethanol-seeking behaviors in rats.

Harry L June1.   

Abstract

The unit outlines four basic protocols designed to systematically evaluate the capacity of potential pharmacotherapeutic agents to effectively treat alcohol addiction and dependence in rats. Also included are procedures designed to study the neural mechanisms regulating alcohol-seeking behaviors.

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Year:  2002        PMID： 18428571     DOI： 10.1002/0471142301.ns0912s19

Source DB:  PubMed          Journal:  Curr Protoc Neurosci        ISSN： 1934-8576


  3 in total

1.  Effects of the triple monoamine uptake inhibitor DOV 102,677 on alcohol-motivated responding and antidepressant activity in alcohol-preferring (P) rats.

Authors:  Andrew R S T Yang; Heon S Yi; Kaitlin T Warnock; Jacek Mamczarz; Harry L June; Nikhil Mallick; Philip A Krieter; Leonardo Tonelli; Phil Skolnick; Anthony S Basile; Harry L June
Journal:  Alcohol Clin Exp Res       Date:  2011-12-07       Impact factor: 3.455

2.  The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors.

Authors:  Scott C Harvey; Katrina L Foster; Pete F McKay; Michelle R Carroll; Regat Seyoum; James E Woods; Collette Grey; Cecily M Jones; Shannan McCane; Rancia Cummings; Dynesha Mason; Chunrong Ma; James M Cook; Harry L June
Journal:  J Neurosci       Date:  2002-05-01       Impact factor: 6.167

3.  A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats.

Authors:  Peter F McKay; Katrina L Foster; Dynesha Mason; Rancia Cummings; Marin Garcia; La Shone Williams; Collette Grey; Shannan McCane; Xiaohui He; James M Cook; Harry L June
Journal:  Psychopharmacology (Berl)       Date:  2003-12-10       Impact factor: 4.530
  3 in total

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