Literature DB >> 18428529

In vivo measurement of blood-brain barrier permeability.

K M Boje1.   

Abstract

This unit describes various protocols for the in vivo quantitation of drug permeability across the rodent blood - brain barrier. Methods for the measurement of drug influx or efflux are described, and support protocols are provided for determining intravascular capillary volume and cerebral perfusion flow. An in situ perfusion technique is also provided for assessing whether transport of a test compound occurs by carrier-mediated or saturable transport.

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Year:  2001        PMID： 18428529     DOI： 10.1002/0471142301.ns0719s15

Source DB:  PubMed          Journal:  Curr Protoc Neurosci        ISSN： 1934-8576


  4 in total

1.  Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig.

Authors:  Matthew K Brittain; Kevin G McGarry; Robert A Moyer; Michael C Babin; David A Jett; Gennady E Platoff; David T Yeung
Journal:  Int J Toxicol       Date:  2016-04-21       Impact factor: 2.032

2.  A high-throughput cell-based method to predict the unbound drug fraction in the brain.

Authors:  André Mateus; Pär Matsson; Per Artursson
Journal:  J Med Chem       Date:  2014-03-20       Impact factor: 7.446

3.  Bacterial melanin crosses the blood-brain barrier in rat experimental model.

Authors:  Tigran Petrosyan; Anichka Hovsepyan
Journal:  Fluids Barriers CNS       Date:  2014-08-25

4.  A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain.

Authors:  Tamio Furuse; Hiroshi Mizuma; Yuuki Hirose; Tomoko Kushida; Ikuko Yamada; Ikuo Miura; Hiroshi Masuya; Hiromasa Funato; Masashi Yanagisawa; Hirotaka Onoe; Shigeharu Wakana
Journal:  Dis Model Mech       Date:  2019-09-12       Impact factor: 5.758
  4 in total

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