Literature DB >> 18427209

Emergence of X4 usage among HIV-1 subtype C: evidence for an evolving epidemic in South Africa.

Bridgette J Connell1, Katherine Michler, Alexio Capovilla, Willem D F Venter, Wendy S Stevens, Maria A Papathanasopoulos.   

Abstract

This study investigated the genotype and phenotype of HIV-1 isolates of 20 South African AIDS patients. We found the highest percentage of CXCR4 usage among primary isolates, in which 30% efficiently utilized CXCR4 and exhibited the syncytium-inducing phenotype. Phylogenetic analysis of env confirmed that 19 of the 20 were subtype C, and syncytium-inducing viruses had genetic changes in the V3 loop, characteristic of CXCR4 usage. Results imply that the frequency of CXCR4-utilizing subtype C is increasing with time.

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Year:  2008        PMID： 18427209     DOI： 10.1097/QAD.0b013e3282f57f7a

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  29 in total

1.  HIV-1 with predicted CXCR4 genotype identified in clade C from India.

Authors:  Abraham Joseph Kandathil; Rajesh Kannangai; Oriapadickal Cherian Abraham; Susanne Alexander Pulimood; Mark A Jensen; Gopalan Sridharan
Journal:  Mol Diagn Ther       Date:  2009       Impact factor: 4.074

2.  Viral tropism and antiretroviral drug resistance in HIV-1 subtype C-infected patients failing highly active antiretroviral therapy in Johannesburg, South Africa.

Authors:  Irene Ketseoglou; Azwidowi Lukhwareni; Kim Steegen; Sergio Carmona; Wendy S Stevens; Maria A Papathanasopoulos
Journal:  AIDS Res Hum Retroviruses       Date:  2013-12-13       Impact factor: 2.205

3.  Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa.

Authors:  Taryn N Green; Mohendran Archary; Michelle L Gordon; Nagavelli Padayachi; Yolanda Lie; Elizabeth D Anton; Jacqueline D Reeves; Anneke Grobler; Raziya Bobat; Hoosen Coovadia; Thumbi Ndung'u
Journal:  AIDS Res Hum Retroviruses       Date:  2011-08-05       Impact factor: 2.205

4.  Individuals with HIV-1 Subtype C Infection and Cryptococcal Meningitis Exhibit Viral Genetic Intermixing of HIV-1 Between Plasma and Cerebrospinal Fluid and a High Prevalence of CXCR4-Using Variants.

Authors:  Katlego Sojane; Richard T Kangethe; Christina C Chang; Mahomed-Yunus S Moosa; Sharon R Lewin; Martyn A French; Thumbi Ndung'u
Journal:  AIDS Res Hum Retroviruses       Date:  2018-05-23       Impact factor: 2.205

5.  Coreceptor usage, diversity, and divergence in drug-naive and drug-exposed individuals from Malawi, infected with HIV-1 subtype C for more than 20 years.

Authors:  Ishla Seager; Simon A Travers; Michael D Leeson; Amelia C Crampin; Neil French; Judith R Glynn; Grace P McCormack
Journal:  AIDS Res Hum Retroviruses       Date:  2014-07-29       Impact factor: 2.205

Review 6.  Bioinformatic analysis of HIV-1 entry and pathogenesis.

Authors:  Benjamas Aiamkitsumrit; Will Dampier; Gregory Antell; Nina Rivera; Julio Martin-Garcia; Vanessa Pirrone; Michael R Nonnemacher; Brian Wigdahl
Journal:  Curr HIV Res       Date:  2014       Impact factor: 1.581

7.  Profile of HIV type 1 coreceptor tropism among Kenyan patients from 2009 to 2010.

Authors:  Anthony Kebira Nyamache; Anne W T Muigai; Zipporah Ng'ang'a; Samoel A Khamadi
Journal:  AIDS Res Hum Retroviruses       Date:  2013-05-21       Impact factor: 2.205

8.  Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease--indication of an evolving epidemic in West Africa.

Authors:  Joakim Esbjörnsson; Fredrik Månsson; Wilma Martínez-Arias; Elzbieta Vincic; Antonio J Biague; Zacarias J da Silva; Eva Maria Fenyö; Hans Norrgren; Patrik Medstrand
Journal:  Retrovirology       Date:  2010-03-22       Impact factor: 4.602

9.  Neutralization of X4- and R5-tropic HIV-1 NL4-3 variants by HOCl-modified serum albumins.

Authors:  Svenja Polzer; Melanie van Yperen; Martin Kirst; Birco Schwalbe; Heiner Schaal; Michael Schreiber
Journal:  BMC Res Notes       Date:  2010-06-02

10.  Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission.

Authors:  Laura Heath; Susan Conway; Laura Jones; Katherine Semrau; Kyle Nakamura; Jan Walter; W Don Decker; Jason Hong; Thomas Chen; Marintha Heil; Moses Sinkala; Chipepo Kankasa; Donald M Thea; Louise Kuhn; James I Mullins; Grace M Aldrovandi
Journal:  PLoS One       Date:  2010-04-20       Impact factor: 3.240
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