Literature DB >> 1842701

D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain.

I P Chessell1, A W Procter, P T Francis, D M Bowen.   

Abstract

The action of D-Cycloserine (DCS) at the strychnine-insensitive glycine recognition site of the NMDA receptor-ionophore complex has been studied with membranes from inferior parietal cortex of patients with Alzheimer's disease. The maximal response of the site, measured using [3H]MK-801 binding, was 64% of that observed with glycine. Stimulation of binding induced by DCS in the presence of fixed concentrations of glycine resulted in a family of dose-response curves, consistent with the antibiotic having the property of a partial agonist at this glycine site. It is proposed that because of circumscribed glutamatergic pyramidal cell pathology DCS will have benefit for Alzheimer's patients over and above all other types of cognitive impairment.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1842701     DOI： 10.1016/0006-8993(91)91668-q

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  Treatment of Alzheimer's disease.

Authors:  D M Bowen; P T Francis; A W Procter; A B Young
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-04       Impact factor: 10.154

2.  A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients.

Authors:  Donald C Goff; Lawrence Herz; Thomas Posever; Vivian Shih; Guochuan Tsai; David C Henderson; Oliver Freudenreich; A Eden Evins; Iftah Yovel; Hui Zhang; David Schoenfeld
Journal:  Psychopharmacology (Berl)       Date:  2004-10-21       Impact factor: 4.530

3.  Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene.

Authors:  J Alexander Bodkin; Michael J Coleman; Laura J Godfrey; Claudia M B Carvalho; Charity J Morgan; Raymond F Suckow; Thea Anderson; Dost Öngür; Marc J Kaufman; Kathryn E Lewandowski; Arthur J Siegel; Elliot Waldstreicher; Christopher M Grochowski; Daniel C Javitt; Dan Rujescu; Scott Hebbring; Richard Weinshilboum; Stephanie Burgos Rodriguez; Colette Kirchhoff; Timothy Visscher; Alexander Vuckovic; Allison Fialkowski; Shane McCarthy; Dheeraj Malhotra; Jonathan Sebat; Donald C Goff; James I Hudson; James R Lupski; Joseph T Coyle; Uwe Rudolph; Deborah L Levy
Journal:  Biol Psychiatry       Date:  2019-05-09       Impact factor: 13.382

4.  Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Authors:  Hirosha Geekiyanage; Aditi Upadhye; Christina Chan
Journal:  Neurobiol Aging       Date:  2013-03-23       Impact factor: 4.673

5.  Postnatal changes in N-methyl-D-aspartate receptor binding and stimulation by glutamate and glycine of [3H]-MK-801 binding in human temporal cortex.

Authors:  P Slater; S E McConnell; S W D'Souza; A J Barson
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

Review 6.  D-cycloserine for Alzheimer's disease.

Authors:  K Laake; A R Oeksengaard
Journal:  Cochrane Database Syst Rev       Date:  2002

Review 7.  NMDA receptors in clinical neurology: excitatory times ahead.

Authors:  Lorraine V Kalia; Suneil K Kalia; Michael W Salter
Journal:  Lancet Neurol       Date:  2008-08       Impact factor: 44.182

Review 8.  The glutamatergic system and Alzheimer's disease: therapeutic implications.

Authors:  D Allan Butterfield; Chava B Pocernich
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

9.  Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression.

Authors:  P T Francis; M N Pangalos; P H Stephens; J R Bartlett; P K Bridges; A L Malizia; D Neary; A W Procter; D J Thomas; D M Bowen
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-01       Impact factor: 10.154

Review 10.  Serine racemase: a key player in apoptosis and necrosis.

Authors:  Nadia Canu; Maria Teresa Ciotti; Loredano Pollegioni
Journal:  Front Synaptic Neurosci       Date:  2014-04-21
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.