Literature DB >> 18426895

Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.

Markus Mezger1, Iwona Wozniok, Christian Blockhaus, Oliver Kurzai, Holger Hebart, Hermann Einsele, Juergen Loeffler.   

Abstract

Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.

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Year:  2008        PMID： 18426895      PMCID： PMC2443887          DOI： 10.1128/AAC.01618-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Automated RNA extraction by MagNA Pure followed by rapid quantification of cytokine and chemokine gene expression with use of fluorescence resonance energy transfer.

Authors:  Juergen Loeffler; Phillipp Swatoch; Diana Akhawi-Araghi; Holger Hebart; Hermann Einsele
Journal:  Clin Chem       Date:  2003-06       Impact factor: 8.327

Review 2.  Dendritic cells: emerging pharmacological targets of immunosuppressive drugs.

Authors:  Holger Hackstein; Angus W Thomson
Journal:  Nat Rev Immunol       Date:  2004-01       Impact factor: 53.106

3.  Mycophenolic acid upregulates B7-DC expression on dendritic cells, which is associated with impaired allostimulatory capacity of dendritic cells.

Authors:  L Geng; G Jiang; H Xie; Y Fang; S Dong; Y Chen; M Shen; S Zheng
Journal:  Transplant Proc       Date:  2006-06       Impact factor: 1.066

Review 4.  Mycophenolate mofetil and its mechanisms of action.

Authors:  A C Allison; E M Eugui
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5.  Inosine 5'-monophosphate dehydrogenase inhibition by mycophenolic acid impairs maturation and function of dendritic cells.

Authors:  Peter C Dubsky; Josef Friedl; Anton Stift; Thomas Bachleitner-Hofmann; Raimund Jakesz; Michael F X Gnant; Guenter Weigel
Journal:  Clin Chim Acta       Date:  2005-07-26       Impact factor: 3.786

6.  In vitro effects of nonesterified fatty acids on bovine neutrophils oxidative burst and viability.

Authors:  D Scalia; N Lacetera; U Bernabucci; K Demeyere; L Duchateau; C Burvenich
Journal:  J Dairy Sci       Date:  2006-01       Impact factor: 4.034

7.  Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells.

Authors:  M Colic; Z Stojic-Vukanic; B Pavlovic; D Jandric; I Stefanoska
Journal:  Clin Exp Immunol       Date:  2003-10       Impact factor: 4.330

8.  The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.

Authors:  Franziska Lessing; Olaf Kniemeyer; Iwona Wozniok; Juergen Loeffler; Oliver Kurzai; Albert Haertl; Axel A Brakhage
Journal:  Eukaryot Cell       Date:  2007-10-05

9.  Human cytomegalovirus induces a direct inhibitory effect on antigen presentation by monocyte-derived immature dendritic cells.

Authors:  Ulrich Grigoleit; Susanne Riegler; Hermann Einsele; Kerstin Laib Sampaio; Gerhard Jahn; Holger Hebart; Peter Brossart; Friderike Frank; Christian Sinzger
Journal:  Br J Haematol       Date:  2002-10       Impact factor: 6.998

Review 10.  Cellular immunity to viral and fungal antigens after stem cell transplantation.

Authors:  Hermann Einsele; Holger Hebart
Journal:  Curr Opin Hematol       Date:  2002-11       Impact factor: 3.284
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  11 in total

1.  β-Carotene Biosynthesis in Probiotic Bacteria.

Authors:  Jennifer K Miller; M Travis Harrison; Annalisa D'Andrea; Aaron N Endsley; Fangfang Yin; Krishna Kodukula; Douglas S Watson
Journal:  Probiotics Antimicrob Proteins       Date:  2013-06       Impact factor: 4.609

2.  RNA-sequencing analysis of 5' capped RNAs identifies many new differentially expressed genes in acute hepatitis C virus infection.

Authors:  Neven Papic; Christopher I Maxwell; Don A Delker; Shuanghu Liu; Bret S E Heale; Curt H Hagedorn
Journal:  Viruses       Date:  2012-04-16       Impact factor: 5.048

3.  The modular nature of dendritic cell responses to commensal and pathogenic fungi.

Authors:  Lisa Rizzetto; Sonja I Buschow; Luca Beltrame; Carl G Figdor; Stephan Schierer; Gerold Schuler; Duccio Cavalieri
Journal:  PLoS One       Date:  2012-08-03       Impact factor: 3.240

Review 4.  Host response to Candida albicans bloodstream infection and sepsis.

Authors:  Seána Duggan; Ines Leonhardt; Kerstin Hünniger; Oliver Kurzai
Journal:  Virulence       Date:  2015-03-18       Impact factor: 5.882

Review 5.  Purine Acquisition and Synthesis by Human Fungal Pathogens.

Authors:  Jessica L Chitty; James A Fraser
Journal:  Microorganisms       Date:  2017-06-08

6.  Phage Therapy: Beyond Antibacterial Action.

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Journal:  Front Med (Lausanne)       Date:  2018-05-23

7.  Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation.

Authors:  Biljana Smiljanovic; Andreas Grützkau; Till Sörensen; Joachim R Grün; Thomas Vogl; Marc Bonin; Pascal Schendel; Bruno Stuhlmüller; Anne Claussnitzer; Sandra Hermann; Sarah Ohrndorf; Karlfried Aupperle; Marina Backhaus; Andreas Radbruch; Gerd R Burmester; Thomas Häupl
Journal:  Sci Rep       Date:  2020-05-13       Impact factor: 4.379

8.  Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions.

Authors:  Yared H Kidane; Christopher Lawrence; T M Murali
Journal:  BMC Microbiol       Date:  2013-10-07       Impact factor: 3.605

9.  DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells.

Authors:  Xue Zhang; Ashley Ulm; Hari K Somineni; Sunghee Oh; Matthew T Weirauch; Hong-Xuan Zhang; Xiaoting Chen; Maria A Lehn; Edith M Janssen; Hong Ji
Journal:  Epigenetics Chromatin       Date:  2014-08-20       Impact factor: 4.954

10.  Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers.

Authors:  Lisa M Fleischer; Rachana D Somaiya; Gregory M Miller
Journal:  Front Pharmacol       Date:  2018-06-26       Impact factor: 5.810
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