Complete protection of sodium valproate from humidity by using a hydrotalcite composite.

Complete protection of sodium valproate from humidity was successfully accomplished by intercalation into a hydrotalcite-like compound. The obtained hybrid of sodium valproate and the hydrotalcite-like compound was stable and not at all hygroscopic. Even under a relative humidity of 97%, the adsorbed amount of water was less than 0.5%. (c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association