Literature DB >> 18425416

Heparanase involvement in physiology and disease.

N J Nasser1.   

Abstract

Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix. The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing. Heparanase is implicated in a variety of pathologies, such as tumor growth, angiogenesis, metastasis, inflammation, and glomerular diseases. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy.

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Year:  2008        PMID： 18425416     DOI： 10.1007/s00018-008-7584-6

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  38 in total

1.  LC-MS(n) analysis of isomeric chondroitin sulfate oligosaccharides using a chemical derivatization strategy.

Authors:  Rongrong Huang; Vitor H Pomin; Joshua S Sharp
Journal:  J Am Soc Mass Spectrom       Date:  2011-06-23       Impact factor: 3.109

Review 2.  Tissue stiffness dictates development, homeostasis, and disease progression.

Authors:  Andrew M Handorf; Yaxian Zhou; Matthew A Halanski; Wan-Ju Li
Journal:  Organogenesis       Date:  2015       Impact factor: 2.500

Review 3.  Extracellular matrix degradation and remodeling in development and disease.

Authors:  Pengfei Lu; Ken Takai; Valerie M Weaver; Zena Werb
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-12-01       Impact factor: 10.005

4.  Tissue-specificity of heparan sulfate biosynthetic machinery in cancer.

Authors:  Anastasia V Suhovskih; Natalya V Domanitskaya; Alexandra Y Tsidulko; Tatiana Y Prudnikova; Vladimir I Kashuba; Elvira V Grigorieva
Journal:  Cell Adh Migr       Date:  2015       Impact factor: 3.405

Review 5.  mTOR inhibitors and renal allograft: Yin and Yang.

Authors:  Gianluigi Zaza; Simona Granata; Paola Tomei; Valentina Masola; Giovanni Gambaro; Antonio Lupo
Journal:  J Nephrol       Date:  2014-05-08       Impact factor: 3.902

6.  Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells.

Authors:  Liduan Zheng; Guosong Jiang; Hong Mei; Jiarui Pu; Jihua Dong; Xiaohua Hou; Qiangsong Tong
Journal:  BMC Cancer       Date:  2010-02-05       Impact factor: 4.430

Review 7.  The Microenvironment of Tongue Cancer.

Authors:  Want Tao; Zeng Li-Juan; Li Kan; Li Jing-Yuan; Liu Xiang-Qi; Liang Yu-Jie
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

8.  Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.

Authors:  Olga Ostrovsky; Michael Korostishevsky; Itay Shafat; Margarita Mayorov; Neta Ilan; Israel Vlodavsky; Arnon Nagler
Journal:  J Leukoc Biol       Date:  2009-04-30       Impact factor: 4.962

9.  Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation.

Authors:  L F Ferrari; D Araldi; O Bogen; J D Levine
Journal:  Neuroscience       Date:  2016-03-18       Impact factor: 3.590

10.  Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors.

Authors:  Rafael Gozalbes; Silvia Mosulén; Rodrigo J Carbajo; Antonio Pineda-Lucena
Journal:  J Comput Aided Mol Des       Date:  2009-05-07       Impact factor: 3.686
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