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Literature DB >> 18425072

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders.

Gerard Sanacora¹, Carlos A Zarate, John H Krystal, Husseini K Manji.

Abstract

Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide. To date, the monoaminergic systems (serotonergic, noradrenergic and dopaminergic) in the brain have received the greatest attention in neurobiological studies of mood disorders, and most therapeutics target these systems. However, there is growing evidence that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in mood-disorder pathophysiology as well as the efficacy of glutamatergic agents in mood disorders. We also discuss exciting new prospects for the development of improved therapeutics for these devastating disorders.

Entities: Disease

Mesh：

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Year: 2008 PMID： 18425072 PMCID： PMC2715836 DOI： 10.1038/nrd2462

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

175 in total

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281 in total

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