Literature DB >> 18424430

Expanded roles for Chk1 in genome maintenance.

Greg H Enders1.   

Abstract

Chk1 is a conserved kinase that imposes cell cycle delays in response to impediments to DNA replication. Recent experiments have further defined effects of Chk1 on the activity of mammalian origins of DNA replication and progression of replication forks. Moreover, Chk1 now appears to help defend genomic integrity through effects on several other pathways, including Fanconi anemia proteins, the mitotic spindle, and transcription of cell cycle-related genes. These findings can account for the requirement for Chk1 in normal proliferating cells of the early embryo and suggest the potential for diverse effects of Chk1 inhibition in cancer therapy.

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Year:  2008        PMID： 18424430      PMCID： PMC2440615          DOI： 10.1074/jbc.R800021200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  32 in total

1.  Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.

Authors:  Hiroyuki Niida; Yuko Katsuno; Birendranath Banerjee; M Prakash Hande; Makoto Nakanishi
Journal:  Mol Cell Biol       Date:  2007-01-22       Impact factor: 4.272

Review 2.  Chromatin modifications and their function.

Authors:  Tony Kouzarides
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

3.  The structural determinants of checkpoint activation.

Authors:  Christina A MacDougall; Tony S Byun; Christopher Van; Muh-ching Yee; Karlene A Cimprich
Journal:  Genes Dev       Date:  2007-04-15       Impact factor: 11.361

4.  Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

Authors:  Yasumichi Inoue; Masatoshi Kitagawa; Yoichi Taya
Journal:  EMBO J       Date:  2007-03-22       Impact factor: 11.598

5.  Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells.

Authors:  Chiara Conti; Barbara Saccà; John Herrick; Claude Lalou; Yves Pommier; Aaron Bensimon
Journal:  Mol Biol Cell       Date:  2007-05-23       Impact factor: 4.138

6.  Chk1 is required for spindle checkpoint function.

Authors:  George Zachos; Elizabeth J Black; Mark Walker; Mary T Scott; Paola Vagnarelli; William C Earnshaw; David A F Gillespie
Journal:  Dev Cell       Date:  2007-02       Impact factor: 12.270

7.  Chk1 frameshift mutation in sporadic and hereditary non-polyposis colorectal cancers with microsatellite instability.

Authors:  C J Kim; J H Lee; J W Song; Y G Cho; S Y Kim; S W Nam; N J Yoo; W S Park; J Y Lee
Journal:  Eur J Surg Oncol       Date:  2007-04-03       Impact factor: 4.424

8.  Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.

Authors:  Massimo Bogliolo; Alex Lyakhovich; Elsa Callén; Maria Castellà; Enrico Cappelli; María J Ramírez; Amadeu Creus; Ricard Marcos; Reinhard Kalb; Kornelia Neveling; Detlev Schindler; Jordi Surrallés
Journal:  EMBO J       Date:  2007-02-15       Impact factor: 11.598

9.  Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway.

Authors:  Xiaozhe Wang; Richard D Kennedy; Kallol Ray; Patricia Stuckert; Tom Ellenberger; Alan D D'Andrea
Journal:  Mol Cell Biol       Date:  2007-02-12       Impact factor: 4.272

10.  The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.

Authors:  Jennifer A Seiler; Chiara Conti; Ali Syed; Mirit I Aladjem; Yves Pommier
Journal:  Mol Cell Biol       Date:  2007-05-21       Impact factor: 4.272
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  33 in total

1.  Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.

Authors:  Sanjay Kumar; Hae Yong Yoo; Akiko Kumagai; Anna Shevchenko; Andrej Shevchenko; William G Dunphy
Journal:  Cell Cycle       Date:  2012-03-15       Impact factor: 4.534

2.  Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

Authors:  Jacob G Jansen; Anastasia Tsaalbi-Shtylik; Giel Hendriks; Himabindu Gali; Ayal Hendel; Fredrik Johansson; Klaus Erixon; Zvi Livneh; Leon H F Mullenders; Lajos Haracska; Niels de Wind
Journal:  Mol Cell Biol       Date:  2009-03-30       Impact factor: 4.272

3.  The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.

Authors:  Michael G Kemp; Laura A Lindsey-Boltz; Aziz Sancar
Journal:  J Biol Chem       Date:  2011-04-12       Impact factor: 5.157

4.  Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.

Authors:  Deborah Wilsker; Jon H Chung; Fred Bunz
Journal:  Cell Cycle       Date:  2012-04-15       Impact factor: 4.534

5.  Cisplatin associated with LY294002 increases cytotoxicity and induces changes in transcript profiles of glioblastoma cells.

Authors:  P O Carminati; F S Donaires; M M Marques; E A Donadi; G A S Passos; E T Sakamoto-Hojo
Journal:  Mol Biol Rep       Date:  2013-11-12       Impact factor: 2.316

Review 6.  The bright and the dark sides of DNA repair in stem cells.

Authors:  Guido Frosina
Journal:  J Biomed Biotechnol       Date:  2010-04-08

7.  Analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome.

Authors:  Sami Kilpinen; Kalle Ojala; Olli Kallioniemi
Journal:  PLoS One       Date:  2010-12-03       Impact factor: 3.240

8.  DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.

Authors:  Van Leung-Pineda; Jiwon Huh; Helen Piwnica-Worms
Journal:  Cancer Res       Date:  2009-03-10       Impact factor: 12.701

9.  Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival.

Authors:  Jill M Wagner; Larry M Karnitz
Journal:  Mol Pharmacol       Date:  2009-04-29       Impact factor: 4.436

10.  Chk1 haploinsufficiency results in anemia and defective erythropoiesis.

Authors:  Nathan C Boles; Sirisha Peddibhotla; Alice J Chen; Margaret A Goodell; Jeffrey M Rosen
Journal:  PLoS One       Date:  2010-01-05       Impact factor: 3.240
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