| Literature DB >> 18424134 |
Giorgio Ortar1, Aniello Schiano Moriello, Maria Grazia Cascio, Luciano De Petrocellis, Alessia Ligresti, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo.
Abstract
A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC(50)=2.3-5.1microM) and selectively over other proteins involved in endocannabinoid action and metabolism.Entities:
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Year: 2008 PMID： 18424134 DOI： 10.1016/j.bmcl.2008.04.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823