| Literature DB >> 18424096 |
Markus Rauchenzauner1, Markus Laimer, Gerhard Luef, Susanne Kaser, Julia Engl, Tobias Tatarczyk, Christian Ciardi, Alexander Tschoner, Monika Lechleitner, Josef Patsch, Christoph F Ebenbichler.
Abstract
Valproic acid (VPA) is an effective and widely used anticonvulsant, associated with metabolic adverse effects such as weight gain, hyperinsulinemia, hyperleptinemia and hypoadiponectinemia. The aim of this study was to evaluate the influence of VPA and topiramate (TPM) on adiponectin binding receptors, adipoR1 and adipoR2, in human liver cancer cells, HepG2. AdipoR1 but not adipoR2 gene expression was upregulated by VPA treatment. TPM did neither affect adipoR1 nor adipoR2 gene expression. Given the tight association between VPA treatment, metabolic side effects and the adipocytokine-axis, upregulation of adipoR1 possibly represents a favoured and insulin-sensitizing mechanism.Entities:
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Year: 2008 PMID： 18424096 DOI： 10.1016/j.seizure.2008.03.002
Source DB: PubMed Journal: Seizure ISSN： 1059-1311 Impact factor: 3.184