Literature DB >> 18424045

The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C.

Rohan A Davis1, James Longden, Vicky M Avery, Peter C Healy.   

Abstract

Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.

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Year:  2008        PMID： 18424045     DOI： 10.1016/j.bmcl.2008.03.090

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  Endophytic Penicillium species and their agricultural, biotechnological, and pharmaceutical applications.

Authors:  Rufin Marie Kouipou Toghueo; Fabrice Fekam Boyom
Journal:  3 Biotech       Date:  2020-02-08       Impact factor: 2.406

2.  Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues.

Authors:  Petra E Jans; Adelphe M Mfuh; Hadi D Arman; Corena V Shaffer; Oleg V Larionov; Susan L Mooberry
Journal:  J Nat Prod       Date:  2017-01-04       Impact factor: 4.050

3.  Concise Total Synthesis of Trichodermamides A, B, and C Enabled by an Efficient Construction of the 1,2-Oxazadecaline Core.

Authors:  Adelphe M Mfuh; Yu Zhang; David E Stephens; Anh X T Vo; Hadi D Arman; Oleg V Larionov
Journal:  J Am Chem Soc       Date:  2015-06-22       Impact factor: 15.419

4.  Biochemical constituents of a wild strain of Schizophyllum commune isolated from Achanakmar-Amarkantak Biosphere Reserve (ABR), India.

Authors:  Arpita Mani Tripathi; Bhupendra N Tiwary
Journal:  World J Microbiol Biotechnol       Date:  2013-03-09       Impact factor: 3.312

Review 5.  Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery.

Authors:  Pragya Tiwari; Hanhong Bae
Journal:  Microorganisms       Date:  2022-02-04

6.  Endophytic fungi from Myrcia guianensis at the Brazilian Amazon: distribution and bioactivity.

Authors:  Elissandro Fonseca Dos Banhos; Antonia Queiroz Lima de Souza; Juliano Camurça de Andrade; Afonso Duarte Leão de Souza; Hector Henrique Ferreira Koolen; Patrícia Melchionna Albuquerque
Journal:  Braz J Microbiol       Date:  2014-04-11       Impact factor: 2.476

Review 7.  Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review.

Authors:  Fazilath Uzma; Chakrabhavi D Mohan; Abeer Hashem; Narasimha M Konappa; Shobith Rangappa; Praveen V Kamath; Bhim P Singh; Venkataramana Mudili; Vijai K Gupta; Chandra N Siddaiah; Srinivas Chowdappa; Abdulaziz A Alqarawi; Elsayed F Abd Allah
Journal:  Front Pharmacol       Date:  2018-04-26       Impact factor: 5.810

8.  Hatsusamides A and B: Two New Metabolites Produced by the Deep-Sea-Derived Fungal Strain Penicillium steckii FKJ-0213.

Authors:  Hirotaka Matsuo; Rei Hokari; Aki Ishiyama; Masato Iwatsuki; Mayuka Higo; Kenichi Nonaka; Yuriko Nagano; Yōko Takahashi; Satoshi Ōmura; Takuji Nakashima
Journal:  Mar Drugs       Date:  2020-10-12       Impact factor: 5.118
  8 in total

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